Supramolecular polymers: A perspective on the stability, biocompatibility and regulatory aspects

Abstract

Supramolecular polymers represent a distinctive class of polymers exhibiting similarities with covalent polymers, while also showcasing distinctive attributes such as responsiveness, reversibility, self-healing, and dynamism, which are conferred upon them by non-covalent interactions including hydrogen bonding, electrostatic interactions, van der Waals forces, π-π arrangements, and donor–acceptor interactions, among others. The noteworthy features of these supramolecular polymers have attracted considerable interest across diverse fields of science and technology, spanning electrochemistry, environmental science, drug delivery and tissue engineering. Nonetheless, the prevailing research focus in the realm of supramolecular polymers revolves around the advancement of novel methodologies aimed at synthesizing a broad spectrum of polymers characterized by diverse topologies. However, to fully capitalize on their potential applications within these domains, it is imperative to scrutinize these versatile polymers through the lens of thermodynamic and kinetic stability. Moreover, their integration into healthcare and medical realms necessitates rigorous assessment of safety and biocompatibility attributes. Thus, the present review endeavours to critically evaluate supramolecular polymers from perspectives of stability, safety, and regulatory considerations, thereby elucidating their potential for translation into commercial domains.