Characterization of receptive fields in the dorsal lateral geniculate nucleus of the tammar wallaby.

Abstract

Orientation selectivity is a prominent feature of neurons in the mammalian primary visual cortex (V1), yet its emergence along the visual pathway varies across species. In carnivores and primates, neurons with elongated and orientation-selective receptive fields (RFs) emerge in V1, whereas in mice such RFs appear earlier, in the retina or dorsal lateral geniculate nucleus (dLGN). Here, we investigate the RF properties of neurons in the dLGN of a marsupial, the wallaby (Macropus eugenii) (n = 2; males), using multichannel electrodes and nonlinear input model (NIM) analysis. Do dLGN RFs resemble those of carnivores and primates or exhibit unique characteristics, particularly regarding orientation selectivity? We found that 82% of neurons have a predominant ON-center response. We identified two main cell types: X-cells (n = 15/22), which exhibit linear properties, and Y-cells (n = 7/22), which display nonlinear characteristics. Most dLGN RFs were blob-like and lacked the oriented structures seen in cortical neurons but some had slightly elongated central areas. These results indicate that robust orientation selectivity develops fully in V1 (76% of neurons). However, mild orientation biases were observed in 41% of dLGN neurons. This study enhances our understanding of visual processing in marsupials and underscores the evolutionary significance of orientation selectivity in mammalian visual pathways.NEW & NOTEWORTHY This study examines receptive field (RF) properties of neurons in the dorsal lateral geniculate nucleus (dLGN) of wallabies using multichannel electrodes and nonlinear input model (NIM) analysis. We identified two main cell types: X-cells (linear) and Y-cells (nonlinear). Most dLGN RFs were blob-like, with mild orientation biases in 41% of neurons, indicating robust orientation selectivity develops fully in primary visual cortex (V1) (76% of neurons).