Ambereen Kidwai, Mingzhu Hou, Marianne de Chastelaine, Michael D. Rugg
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引用次数: 0
Abstract
The present study examines whether structural and functional variability in medial temporal lobe (MTL) neocortical regions correlate with individual differences in episodic memory and longitudinal memory change in cognitively healthy older adults. To address this question, older adults were administered a battery of neuropsychological tests on three occasions: the second occasion one month after the first test session, and a third session three years later. Structural and functional MRI data were acquired between the first two sessions and included an in-scanner associative recognition procedure enabling estimation of MTL encoding and recollection fMRI BOLD effects. Encoding effects in parahippocampal cortex correlated with associative recognition performance and baseline cognitive ability. Recollection effects in entorhinal cortex correlated with associative recognition performance and predicted memory change over the three-year follow-up interval, an association that remained after controlling for chronological age and entorhinal cortical volume. These findings suggest that entorhinal recollection effects may be indicative of the future functional integrity of the region and, hence, its capacity to support future memory performance.
期刊介绍:
Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.