Role of immunotherapy in the overall survival of gastrointestinal cancer patients with liver metastases.

IF 1.3 Q4 ONCOLOGY Hepatic Oncology Pub Date : 2024-12-31 Epub Date: 2024-09-27 DOI:10.1080/20450923.2024.2403323

Taoyuan M Beninato, Saber A Amin, Michael J Baine, Chi Lin

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Abstract

Aim: To investigate the role of immunotherapy in the overall survival (OS) of gastrointestinal cancer patients who have liver metastases at the time of the primary site cancer diagnosis.Materials & methods: Survival outcome was compared between groups with immunotherapy and groups without immunotherapy.Results: Chemoimmunotherapy was associated with improved OS (hazard ratio [HR] 0.768; 95% CI 0.739-0.800; p < 0.001) compared with chemotherapy alone. Radiotherapy to the primary site plus chemoimmunotherapy was also associated with improved OS (HR 0.796; 95% CI 0.705-0.898; p < 0.001) compared to chemoradiation. Chemoimmunotherapy with radiotherapy to metastatic sites (except liver) was associated with improved OS (HR 0.771; 95% CI 0.706-0.842; p < 0.001) compared to chemoradiation.Conclusion: Immunotherapy plus chemotherapy or chemoradiation was associated with improved OS compared with chemotherapy or chemoradiation without immunotherapy.

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免疫疗法在消化道癌症肝转移患者总生存期中的作用。

目的：探讨免疫治疗在原发部位肿瘤诊断时发生肝转移的胃肠道肿瘤患者总生存期（OS）中的作用。材料与方法：比较免疫治疗组与非免疫治疗组的生存结局。结果：化疗免疫治疗与OS改善相关(风险比[HR] 0.768；95% ci 0.739-0.800；结论：与不加免疫治疗的化疗或放化疗相比，免疫治疗加化疗或放化疗可改善OS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatic Oncology ONCOLOGY-

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Primary liver cancer is the sixth most common cancer in the world, and the third most common cause of death from malignant disease. Traditionally more common in developing countries, hepatocellular carcinoma is becoming increasingly prevalent in the Western world, primarily due to an increase in hepatitis C virus infection. Emerging risk factors, such as non-alcoholic fatty liver disease and obesity are also of concern for the future. In addition, metastatic tumors of the liver are more common than primary disease. Some studies report hepatic metastases in as many as 40 to 50% of adult patients with extrahepatic primary tumors. Hepatic Oncology publishes original research studies and reviews addressing preventive, diagnostic and therapeutic approaches to all types of cancer of the liver, in both the adult and pediatric populations. The journal also highlights significant advances in basic and translational research, and places them in context for future therapy. Hepatic Oncology provides a forum to report and debate all aspects of cancer of the liver and bile ducts. The journal publishes original research studies, full reviews and commentaries, with all articles subject to independent review by a minimum of three independent experts. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.