Temporal trends of the incidence rate of syphilis during pregnancy and congenital syphilis in São Paulo, Brazil, 2011-2023.

IF 2 Q1 Multidisciplinary Epidemiologia e Servicos de Saude Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI:10.1590/S2237-96222024v33e2024637.en

Beatriz Poddis Busquim E Silva, Fernanda Penido Matozinhos, Rafaela Siqueira Costa Schreck, Fernanda Marçal Ferreira, Camilla Pontes Bezerra, Bárbara Tideman Sartório Camargo, Thales Philipe Rodrigues da Silva

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Abstract

Objective: To analyze trends of syphilis during pregnancy and congenital syphilis, based on reported cases in São Paulo, Brazil, from 2011 to 2023.

Methods: Ecological time series study, based on data from Notifiable Health Conditions Information System records. The Prais-Winsten method was used to verify trends.

Results: 125,776 cases of syphilis during pregnancy and 42,418 cases of congenital syphilis were reported. Average annual percentage change (95%CI) in the syphilis during pregnancy incidence rate was 18.68 (95%CI 16.57; 20.84), pvalue < 0.001; while for congenital syphilis it was 11.99 (95%CI 7.00; 17.22), p-value < 0.001.

Conclusion: Incidence rates of syphilis during pregnancy and congenital syphilis showed significant increasing trends, which may be related to the increase in the former during the diagnosis period (1st trimester), demonstrating increased testing among pregnant women, clinical classification at the time of diagnosis (latent syphilis), as well as inefficiency of adequate treatment when diagnosis is late.

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2011-2023年巴西圣保罗妊娠期梅毒和先天性梅毒发病率的时间趋势

目的：分析2011 - 2023年巴西圣保罗地区妊娠期梅毒和先天性梅毒的流行趋势。方法：采用生态时间序列研究，数据来源于应通报健康状况信息系统。Prais-Winsten方法用于验证趋势。结果：共报告妊娠期梅毒125776例，先天性梅毒42418例。妊娠期梅毒发病率年平均变化百分比（95%CI）为18.68 (95%CI 16.57；20.84)， p值< 0.001；先天性梅毒为11.99 (95%CI 7.00)；17.22)， p值< 0.001。结论：妊娠期梅毒和先天性梅毒的发病率呈明显上升趋势，这可能与前者在诊断期（妊娠早期）发病率上升有关，表现为孕妇检测增多、诊断时临床分型（潜伏性梅毒）以及诊断较晚时治疗不到位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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