{"title":"The leader proteinase of foot-and-mouth disease virus: Efficiency through exosites","authors":"Tim Skern","doi":"10.1016/j.virol.2025.110420","DOIUrl":null,"url":null,"abstract":"<div><div>Viruses were shown to encode proteinases in the 1970s. Initially, it was assumed that they would be only used for proteolytic processing of the viral proteins. Subsequent investigations showed that such proteinases could affect host metabolism to benefit viral replication. The foot-and-mouth disease virus (FMDV) leader proteinase (Lb<sup>pro</sup>) cleaves several specific cellular targets. This mini-review summarises the cellular targets of Lb<sup>pro</sup> and illustrates the protein interactions away from the canonical substrate binding sites that Lb<sup>pro</sup> has evolved to enable specific and efficient cleavage of host proteins to promote FMDV replication.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"604 ","pages":"Article 110420"},"PeriodicalIF":2.4000,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0042682225000327","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Viruses were shown to encode proteinases in the 1970s. Initially, it was assumed that they would be only used for proteolytic processing of the viral proteins. Subsequent investigations showed that such proteinases could affect host metabolism to benefit viral replication. The foot-and-mouth disease virus (FMDV) leader proteinase (Lbpro) cleaves several specific cellular targets. This mini-review summarises the cellular targets of Lbpro and illustrates the protein interactions away from the canonical substrate binding sites that Lbpro has evolved to enable specific and efficient cleavage of host proteins to promote FMDV replication.
期刊介绍：
Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.
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