Clinical and sociodemographic characteristics of alzheimer's disease and related dementias (AD/ADRD) among people living with HIV: a cross-sectional analysis.
Monique J Brown, Nyame Mustapha Murtala, Daniel Amoatika, Amandeep Kaur, Prince Nii Ossah Addo, Medinat Omobola Osinubi, Maggi Miller, Lucy A Ingram
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引用次数: 0
Abstract
Introduction: Alzheimer's disease and related dementias (AD/ADRD) continue to be a public health challenge. People living with HIV (PLWH) are at risk for neurocognitive disorders and may be at risk for AD/ADRD. However, studies examining clinical and sociodemographic factors associated with AD/ADRD among PLWH are lacking. Therefore, the aim of this cross-sectional study was to determine the association between selected sociodemographic (age, gender, race and rurality) and clinical (depression and encephalopathy) factors with (AD/ADRD) among PLWH.
Methods: Data were obtained from the South Carolina Revenue and Fiscal Affairs (RFA) Office and the South Carolina Alzheimer's Disease Registry (N = 13,390). Multivariable logistic regression models were used to determine the association between age, gender, race, rurality, depression and encephalopathy, and AD/ADRD among PLWH.
Results: Among the study population (N = 13,390), 5% (n = 601) were found to have AD/ADRD. There was a dose-response relationship between age group and AD/ADRD whereas the age group increased, the association increased. For example, those who were aged 80 years and older were 80 times more likely to have AD/ADRD compared to those aged 18-29 years (aOR: 80.4; 95% CI: 40.2-160.8). Additionally, male sex (aOR: 1.3; 95% CI: 1.9-1.6) and encephalopathy (aOR: 2.4; 95% CI: 1.9-3.2) were positively associated with AD/ADRD for PLWH.
Conclusion: AD/ADRD interventions may be warranted among PLWH, especially among older adults, men, and those with encephalopathy. Future studies should examine potential pathways between clinical and sociodemographic characteristics and AD/ADRD among PLWH.
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Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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