{"title":"Maximizing the dual benefit of pet dogs in cancer trials","authors":"Jennifer A. Lenz, Matthew J. Atherton","doi":"10.1038/s41568-025-00792-0","DOIUrl":null,"url":null,"abstract":"Pet dogs with cancer have catalysed the translation of preclinical discoveries to first-in-human trials, highlighting the unique power of comparative oncology to study veterinary and human patients with cancer in parallel. However, the full potential of this approach has yet to be harnessed. Here we highlight accomplishments in oncology due to trials in dogs and discuss the next steps to advance comparative oncology. Pet dogs with cancer facilitate comparative oncology, enhancing translational research. In this Comment, Lenz and Atherton highlight comparative oncology successes, emphasizing the need for broader application of findings from canine studies to improve human cancer treatments.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"25 3","pages":"147-148"},"PeriodicalIF":72.5000,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Cancer","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41568-025-00792-0","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pet dogs with cancer have catalysed the translation of preclinical discoveries to first-in-human trials, highlighting the unique power of comparative oncology to study veterinary and human patients with cancer in parallel. However, the full potential of this approach has yet to be harnessed. Here we highlight accomplishments in oncology due to trials in dogs and discuss the next steps to advance comparative oncology. Pet dogs with cancer facilitate comparative oncology, enhancing translational research. In this Comment, Lenz and Atherton highlight comparative oncology successes, emphasizing the need for broader application of findings from canine studies to improve human cancer treatments.
期刊介绍：
Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.
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