{"title":"FIGNL1 hexamer dissociates RAD51-filament: a new mechanism.","authors":"Rajeev Kumar","doi":"10.1016/j.tibs.2025.01.002","DOIUrl":null,"url":null,"abstract":"<p><p>Homologous recombination (HR) is critical for maintaining genome stability, relying on RAD51 recombinase to catalyze homology-dependent accurate DNA repair. While various cellular modulators control HR, Carver, Yu, et al. reveal a unique molecular mechanism used by FIDGETIN-LIKE-1 (FIGNL1) that dissociates RAD51 from DNA through RAD51 N terminus and FIGNL1 hexamer assembly.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.6000,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Biochemical Sciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.tibs.2025.01.002","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Homologous recombination (HR) is critical for maintaining genome stability, relying on RAD51 recombinase to catalyze homology-dependent accurate DNA repair. While various cellular modulators control HR, Carver, Yu, et al. reveal a unique molecular mechanism used by FIDGETIN-LIKE-1 (FIGNL1) that dissociates RAD51 from DNA through RAD51 N terminus and FIGNL1 hexamer assembly.
期刊介绍：
For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.
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