Unraveling the role of the P2X7 receptor in cancer radioresistance: Molecular insights and therapeutic implications

IF 3.7 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Molecular cell research Pub Date : 2025-01-29 DOI:10.1016/j.bbamcr.2025.119910

Seyedeh Nasibeh Mousavikia , Maryam M. Matin , Mohammad Taghi Bahreyni Tossi , Hosein Azimian

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Abstract

The P2X7 receptor, a key player in purinergic signaling, is a crucial factor in modulating the response of cancer cells to radiotherapy. The aim of this study was to elucidate the molecular mechanisms by which P2X7 receptor activation contributes to radioresistance in different cancer types. P2X7 receptor signaling influences cellular processes such as DNA damage repair and inflammatory responses, thereby improving tumor survival after radiation exposure. Activation of the P2X7 receptor leads to changes in the tumor microenvironment and promotes an adaptive response that enables cancer cells to resist therapeutic interventions. Therefore, targeting the P2X7 receptor could represent a new therapeutic strategy against cancer. By linking molecular insights with therapeutic implications, this research highlights the P2X7 receptor as a promising target for overcoming radioresistance in cancer therapy and paves the way for novel combination approaches that could significantly improve patient outcomes.

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揭示P2X7受体在癌症放射耐药中的作用：分子见解和治疗意义。

P2X7受体是嘌呤能信号传导的关键参与者，是调节癌细胞对放疗反应的关键因素。本研究的目的是阐明P2X7受体激活促进不同类型癌症放射耐药的分子机制。P2X7受体信号传导影响细胞过程，如DNA损伤修复和炎症反应，从而提高辐射暴露后肿瘤的存活率。P2X7受体的激活导致肿瘤微环境的变化，并促进适应性反应，使癌细胞能够抵抗治疗干预。因此，靶向P2X7受体可能代表了一种新的治疗癌症的策略。通过将分子见解与治疗意义联系起来，本研究突出了P2X7受体作为克服癌症治疗中放射耐药的有希望的靶点，并为可以显着改善患者预后的新型联合方法铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular cell research 生物-生化与分子生物学

CiteScore

10.00

自引率

2.00%

发文量

151

审稿时长

44 days

期刊介绍： BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.