Altered individual-based morphological brain network in type 2 diabetes mellitus

IF 3.5 3区医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2025-01-30 DOI:10.1016/j.brainresbull.2025.111228

Wang Yan , Ge Limin , Sun Zhizhong , Cao Zidong , Qiu Shijun

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Abstract

Type 2 diabetes mellitus (T2DM) is recognized as a risk factor for cognitive decline, potentially linked to disrupted network connectivity. However, few previous studies have examined individual-based morphological brain networks in T2DM and their association with clinical characteristics. In our study, we enrolled 123 patients with T2DM and 91 healthy controls (HC). We constructed the networks using symmetric Kullback–Leibler (KL) divergence-based similarity (KLS) and calculated various global and nodal metrics based on graph theory to describe the topological properties of the networks. Firstly, T2DM exhibited increased nodal degree in the left para-hippocampus, left amygdala, left precuneus, bilateral putamen, and right inferior temporal gyrus, and the concentrations of glycosylated hemoglobin (HbA1c) were positively correlated with the nodal degree of the left precuneus. Secondly, we identified hypo-connected and hyper-connected subnetworks, primarily involved with reward circuits and attention network, respectively. Lastly, altered morphological connectivity (MC) was linked to cognitive performance, and the aforementioned subnetworks may serve as predictors of cognitive performance. In conclusion, this study provided neuroimaging evidence for understanding cognitive changes by analyzing the properties and connections of individual-based morphological brain networks (MBNs) in T2DM patients.

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2 型糖尿病（T2DM）被认为是认知能力下降的一个危险因素，这可能与网络连接中断有关。然而，之前很少有研究对 T2DM 患者基于个体的大脑形态网络及其与临床特征的关系进行研究。在我们的研究中，我们招募了 123 名 T2DM 患者和 91 名健康对照组（HC）。我们使用基于对称KL发散的相似性（KLS）构建了网络，并基于图论计算了各种全局和节点指标，以描述网络的拓扑特性。首先，T2DM表现出左侧海马旁、左侧杏仁核、左侧楔前肌、双侧普托马和右侧颞下回的节点度增加，糖化血红蛋白（HbA1c）浓度与左侧楔前肌的节点度呈正相关。其次，我们发现了低连接和高连接子网络，分别主要涉及奖赏回路和注意网络。最后，形态连通性（MC）的改变与认知表现有关，上述亚网络可作为认知表现的预测因子。总之，本研究通过分析T2DM患者iSCN的特性和连接，为了解认知变化提供了神经影像学证据。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.