Potential metabolic sequelae to the terrorist attack of October 7th, 2023

IF 3.2 2区医学 Q1 PSYCHIATRY Journal of psychiatric research Pub Date : 2025-02-01 DOI:10.1016/j.jpsychires.2025.01.033

Lawrence Maayan , Eyal Kalanthroff , Ezra Cohen , Yuval Neria

{"title":"Potential metabolic sequelae to the terrorist attack of October 7th, 2023","authors":"Lawrence Maayan , Eyal Kalanthroff , Ezra Cohen , Yuval Neria","doi":"10.1016/j.jpsychires.2025.01.033","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective/hypothesis</h3><div>Evaluate cardiometabolic risk as a potential sequel to a mass terrorist attack using October 7th, 2023 as a focus.</div></div><div><h3>Methods</h3><div>Narrative review surveying PubMed, PsycNet, UN and Council on Foreign Relations websites on.</div><div>1. PTSD following terrorism, rocket attacks and conflict related sexual violence.</div><div>2. The relationship between cardiometabolic illness and PTSD.</div><div>3. Humoral, genetic and epigenetic mechanisms relating cardiometabolic risk, inflammation and PTSD.</div><div>4. Treatments for PTSD and associated cardiometabolic risk factors and their effectiveness.</div></div><div><h3>Findings</h3><div>Cardiometabolic sequelae occur after trauma. This is most pronounced when trauma, sexual or violence related, occurs during childhood. The risk of cardiometabolic sequelae increases with PTSD diagnosis in adults. Inflammation as well as genes related to inflammatory function (e.g. FKBP5, AHRR, NR3C1) impact vulnerability to PTSD, response to treatment and cardiometabolic outcomes. Treatments for PTSD appear somewhat more effective at lowering cardiometabolic risk in civilian, rather than military populations. There is little published research on directly treating cardiometabolic sequelae of PTSD.</div></div><div><h3>Conclusions</h3><div>Israelis, particularly those with exposure to the terror events of October 7, 2023 should be screened for psychological and metabolic sequelae. This should occur in a primary care setting and be part of observational research to help understand relationships between trauma, metabolic outcomes and their treatment.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 452-461"},"PeriodicalIF":3.2000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of psychiatric research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002239562500041X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective/hypothesis

Evaluate cardiometabolic risk as a potential sequel to a mass terrorist attack using October 7th, 2023 as a focus.

Methods

Narrative review surveying PubMed, PsycNet, UN and Council on Foreign Relations websites on.

1. PTSD following terrorism, rocket attacks and conflict related sexual violence.

2. The relationship between cardiometabolic illness and PTSD.

3. Humoral, genetic and epigenetic mechanisms relating cardiometabolic risk, inflammation and PTSD.

4. Treatments for PTSD and associated cardiometabolic risk factors and their effectiveness.

Findings

Cardiometabolic sequelae occur after trauma. This is most pronounced when trauma, sexual or violence related, occurs during childhood. The risk of cardiometabolic sequelae increases with PTSD diagnosis in adults. Inflammation as well as genes related to inflammatory function (e.g. FKBP5, AHRR, NR3C1) impact vulnerability to PTSD, response to treatment and cardiometabolic outcomes. Treatments for PTSD appear somewhat more effective at lowering cardiometabolic risk in civilian, rather than military populations. There is little published research on directly treating cardiometabolic sequelae of PTSD.

Conclusions

Israelis, particularly those with exposure to the terror events of October 7, 2023 should be screened for psychological and metabolic sequelae. This should occur in a primary care setting and be part of observational research to help understand relationships between trauma, metabolic outcomes and their treatment.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

2023年10月7日恐怖袭击的潜在代谢后遗症。

目标/假设：以2023年10月7日为重点，评估大规模恐怖袭击的潜在后果——心脏代谢风险。方法：对PubMed、PsycNet、UN和Council on Foreign Relations网站进行叙述性综述。1. 在恐怖主义、火箭袭击和冲突相关的性暴力之后出现PTSD。2. 心脏代谢疾病与PTSD之间的关系。3. 心脏代谢风险、炎症和创伤后应激障碍相关的体液、遗传和表观遗传机制。4. 创伤后应激障碍及相关心脏代谢危险因素的治疗及其有效性。结果：心脏代谢后遗症发生在创伤后。这在儿童期发生与性或暴力有关的创伤时最为明显。心血管代谢后遗症的风险随着成人PTSD的诊断而增加。炎症以及与炎症功能相关的基因（如FKBP5、AHRR、NR3C1）影响PTSD易感性、对治疗的反应和心脏代谢结果。创伤后应激障碍的治疗在降低平民心脏代谢风险方面似乎比军人更有效。直接治疗创伤后应激障碍的心脏代谢后遗症的研究很少发表。结论：以色列人，特别是那些经历过2023年10月7日恐怖事件的人，应该接受心理和代谢后遗症的筛查。这应该在初级保健环境中进行，并作为观察性研究的一部分，以帮助了解创伤、代谢结果及其治疗之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;