Developing a predictive value for predicting stroke recovery based on transcranial doppler ultrasound parameters

IF 2.7 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS Journal of Neuroscience Methods Pub Date : 2025-01-30 DOI:10.1016/j.jneumeth.2025.110383

Liu Yang, Xinyi Cai, Yanhong Yan, Pinjing Hui

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引用次数: 0

Abstract

Background

One of the leading causes of disability and death is acute ischemic stroke (AIS) brought on by middle cerebral artery (MCA) obstruction. For the best patient care, it is essential to accurately anticipate the functional prognosis in the early stages of stroke. The ability of conventional clinical evaluations and imaging methods to deliver precise and timely prognostic information is frequently limited.

New method

In this work, a predictive value for predicting functional outcome in patients with acute ischemic stroke caused by MCA blockage was developed utilizing transcranial Doppler (TCD) ultrasonography characteristics. Within 24 h after intravenous thrombolysis (IVT), TCD measures such as pulsatility index (PI), mean flow velocity (Vm), end-diastolic velocity (EDV), and peak systolic velocity (PSV) were assessed. Independent determinants of functional outcome, as determined by the modified Rankin Scale (mRS), were found using logistic regression analysis. These important factors were used to create a prediction model.

Comparison with existing methods

Favorable functional outcomes were substantially correlated with a number of TCD characteristics, such as the ratio of pulsatility index to mean flow velocity (rPI) and peak systolic velocity to end-diastolic velocity (rPSV). At three months after a stroke, a logistic regression model that included these measures together with additional clinical indicators showed excellent accuracy in predicting functional prognosis.

Conclusion

In individuals who have experienced an acute ischemic stroke as a result of MCA blockage, TCD ultrasonography parameters—in particular, rPSV and rPI—are useful prognostic indicators for forecasting functional prognosis. Early risk classification and individualized treatment plans can benefit from the creation of a quantitative model based on these criteria. Validating and improving this model in bigger and more varied patient groups should be the goal of future research.

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.