The state of the art in anti-aging: plant-based phytochemicals for skin care.

IF 5.6 2区 医学 Q1 GERIATRICS & GERONTOLOGY Immunity & Ageing Pub Date : 2025-01-31 DOI:10.1186/s12979-025-00498-9
Merve Tomas, Deniz Günal-Köroğlu, Senem Kamiloglu, Tugba Ozdal, Esra Capanoglu
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Abstract

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, and phenolic compounds work by acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, and elastase, which degrade skin structure, and reducing levels of inflammatory markers (IL-6, IL-8, etc.) and matrix metalloproteinases (MMP-1, MMP-2) linked to aging. Recent research highlights that plant-based phytochemicals can improve skin elasticity, reduce hyperpigmentation, prevent the breakdown of important skin proteins, and support wound healing, making them valuable components for skin care and treatments. This review explores the multifaceted roles of phytochemicals in maintaining and improving skin health, highlighting their mechanisms of action and potential in skin anti-aging innovations.

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抗衰老的最新进展:以植物为基础的植物化学物质用于皮肤护理。
植物化学物质通过清除自由基、调节关键的酶通路和促进皮肤的结构完整性来帮助缓解皮肤老化。类胡萝卜素、维生素、必需脂肪酸和酚类化合物的作用是作为抗氧化剂,抑制降解皮肤结构的透明质酸酶、胶原酶和弹性酶等酶,降低与衰老有关的炎症标志物(IL-6、IL-8等)和基质金属蛋白酶(MMP-1、MMP-2)的水平。最近的研究强调,基于植物的植物化学物质可以改善皮肤弹性,减少色素沉着,防止重要皮肤蛋白质的分解,并支持伤口愈合,使其成为皮肤护理和治疗的宝贵成分。本文综述了植物化学物质在维持和改善皮肤健康中的多方面作用,重点介绍了它们在皮肤抗衰老创新中的作用机制和潜力。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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