Recent Advances in DNA-Templated Protein Patterning

IF 9.1 2区 材料科学 Q1 CHEMISTRY, PHYSICAL Small Methods Pub Date : 2025-02-02 DOI:10.1002/smtd.202401835
Qinglin Xia, Mo Zhou, Kai Jiao, Bin Li, Linjie Guo, Lihua Wang, Jiang Li
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Abstract

In recent decades, the advancement of DNA nanotechnology enables precise nanoscale organization of diverse functional materials with DNA templates. Particularly, a variety of DNA-templated protein patterns are constructed as powerful tools for programming biomimetic protein complexes. In this review, recent progress in DNA-templated protein patterning, including cutting-edge methods for arranging proteins with DNA templates, and protein patterns across varying dimensions are briefly summarized. Representative applications in biological analysis and biomedicine are discussed. DNA-protein patterns with programmable dynamics, which hold promise in precision diagnosis and therapeutics are highlighted. Finally, current challenges and opportunities in the fabrication and application of DNA-templated protein pattering are discussed.

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dna模板蛋白图谱的最新进展。
近几十年来,DNA纳米技术的进步使得用DNA模板精确地组织各种功能材料成为可能。特别是,各种dna模板蛋白质模式被构建为编程仿生蛋白质复合物的强大工具。本文综述了DNA模板蛋白图谱研究的最新进展,包括利用DNA模板排列蛋白质的最新方法,以及不同维度的蛋白质图谱。讨论了其在生物分析和生物医学中的代表性应用。具有可编程动力学的dna -蛋白质模式,在精确诊断和治疗中具有前景。最后,讨论了目前dna模板蛋白图谱的制备和应用所面临的挑战和机遇。
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来源期刊
Small Methods
Small Methods Materials Science-General Materials Science
CiteScore
17.40
自引率
1.60%
发文量
347
期刊介绍: Small Methods is a multidisciplinary journal that publishes groundbreaking research on methods relevant to nano- and microscale research. It welcomes contributions from the fields of materials science, biomedical science, chemistry, and physics, showcasing the latest advancements in experimental techniques. With a notable 2022 Impact Factor of 12.4 (Journal Citation Reports, Clarivate Analytics, 2023), Small Methods is recognized for its significant impact on the scientific community. The online ISSN for Small Methods is 2366-9608.
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