Comparison of lifetime attributable risk of post-irradiation secondary cancer of boron neutron capture therapy, proton beam therapy, and X-ray therapy for pediatric and adolescent and young adult patients

Abstract

Background and purpose

This study aimed to compare the post-irradiation secondary cancer rates of boron neutron capture therapy (BNCT), proton beam therapy (PBT), and X-ray therapy (XT) in pediatric and Adolescent and Young Adult (AYA) patients with intracranial lesions.

Materials and methods

BNCT, PBT, and XT plans were optimized for nine pediatric and AYA patients with intracranial lesions. The BNCT dose calculation results were biologically effective dose converted. Lifetime attributable risk (LAR) was calculated using a calculation model proposed by Schneider et al. Statistical analysis was performed using log-linear model with mixed effects. Organs included in the radiation field were the brain, bones, and soft tissue. The difference in LAR between the three treatments for each organ and the number needed to treat (NNT), as an indicator of the number of cases required to achieve the effect of suppressing the occurrence of secondary cancers, was calculated and evaluated.

Results

Statistically significant differences between BNCT vs PBT and XT were confirmed for the brain, bone, soft tissue, and cumulative (P < 0.0001). Significant differences were also observed in PBT and XT, with P < 0.0001 for brain and cumulative, P = 0.0002 for bone, and P = 0.0281 for soft tissue. The cumulative NNT for BNCT vs. PBT, BNCT vs. XT, and PBT vs. XT were 162, 78.6, and 153, respectively.

Conclusion

BNCT had a significantly lower LAR compared to PBT and XT. These findings suggest the usefulness of BNCT in pediatric and AYA patients with brain tumors from the perspective of post-irradiation secondary cancer.