Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-01-28 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S498230

Xinxin Wo, Xiaoyan Yu, Lingling Miao, Yushan Mao, Keke Tang

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Abstract

Purpose: Klinefelter's syndrome (KS) is the most common sex chromosome disorder in the male population and is characterized by the presence of one or more X chromosomes. Studies have reported that the proportion of KS patients with diabetes is not low. It is also not uncommon for diabetes patients with poorly controlled blood glucose to have a transient mild increase in their carcinoembryonic antigen (CEA) levels. This study reports the case of Diabetic ketoacidosis (DKA) concurrently with a significant increase in CEA levels (reaching 40.8 ng/mL) in patients with KS.

Methods: This middle-aged KS patient was immediately treated for DKA upon admission. A series of exams were performed to exclude the possibility of malignant tumors, and the patient's glucose and CEA levels were closely monitored.

Results: After excluding the possibility of malignant tumors, the patient's CEA level gradually decreased to normal after good glycemic control.

Conclusion: This is the first report describing significant increases in CEA levels in KS patients with diabetes, which is of great clinical significance for the treatment of diabetes patients.

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无恶性肿瘤的Klinefelter综合征伴CEA异常升高的糖尿病酮症酸中毒1例报告。

目的：克氏综合征（Klinefelter’s syndrome， KS）是男性人群中最常见的性染色体疾病，其特征是存在一个或多个X染色体。有研究报道，KS患者合并糖尿病的比例并不低。血糖控制不佳的糖尿病患者的癌胚抗原（CEA）水平出现短暂的轻度升高也并不罕见。本研究报道了糖尿病酮症酸中毒（DKA）患者同时CEA水平显著升高（达到40.8 ng/mL）的病例。方法：该中年KS患者入院后立即接受DKA治疗。进行了一系列检查以排除恶性肿瘤的可能性，并密切监测患者的葡萄糖和CEA水平。结果：排除恶性肿瘤可能性后，患者血糖控制良好，CEA水平逐渐降至正常。结论：本文首次报道了KS合并糖尿病患者CEA水平显著升高，对糖尿病患者的治疗具有重要的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.