Deciphering Epigenetic and Post-Translational Modifications in Ferroptosis: A Scientometric and Visualization Study.

Abstract

Background: Recent research emphasizes the significant regulatory functions of epigenetic alterations and post-translational modifications (PTMs) in the ferroptosis process. Despite the existing volume of literature, there is a remarkable shortage of comprehensive analyses that systematically trace the evolution of research, map key investigative routes, evaluate the current situation of the field, determine central themes, and predict future directions. This study intends to offer a comprehensive summary of the progress achieved during the past 12 years in comprehending how epigenetic modifications and PTMs regulate ferroptosis. Methods: The dataset originated from the Web of Science, covering the period from January 1, 2012, to May 21, 2024. By employing advanced analytical tools, we carried out an extensive scientometric assessment in combination with detailed visual data analysis. Results: The results emphasize the crucial role of China, which contributes 69.59% of the global research output, thereby demonstrating its significant influence on the research trajectory in this domain. Remarkable productivity is manifested at institutions such as Central South University, Shanghai Jiao Tong University, and Zhejiang University. Liu Shuang and Tang Daolin stand out as the most productive authors in this field. The journal Cell Death & Disease leads in terms of publication volume, having published the greatest number of articles related to this area. This study identified hepatocellular carcinoma, mitochondrial diseases, and iron overload as the most prominent diseases explored in this research domain. Conclusion: This meticulous scientometric assessment is beneficial to both experienced researchers and newcomers by providing essential information and facilitating the derivation of innovative concepts in this field.