Atopic dermatitis in childhood and pubertal development: A nationwide cohort study

IF 5.2 JAAD International Pub Date : 2025-04-01 Epub Date: 2024-11-21 DOI:10.1016/j.jdin.2024.09.018

Camilla Lomholt Kjersgaard MD , Andreas Ernst MD, PhD , Pernille Jul Clemmensen MD, PhD , Lea Lykke Harrits Lunddorf MD, PhD , Linn Håkonsen Arendt MD, PhD , Nis Brix MD, PhD , Onyebuchi A. Arah MD, PhD , Mette Deleuran MD, PhD , Cecilia Høst Ramlau-Hansen MHSc, PhD

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Abstract

Background

Atopic dermatitis (AD) might delay puberty, but research is lacking.

Objective

To investigate the association between AD and puberty.

Methods

A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at 6 months, 18 months, and 7 years old. The National Patient Registry identified hospital-diagnosed AD. From 11 years, the children give half-yearly information on pubertal development. We estimated the mean age difference in months at attaining Tanner stages 1 to 5 and the development of axillary hair, acne, first ejaculation, voice break, and age at menarche, using an interval-censored regression model.

Results

In total, 15,534 children participated, 21.5% had self-reported doctor-diagnosed AD and 0.7% had hospital-diagnosed AD. For girls with self-reported doctor-diagnosed AD, the average age difference at reaching all pubertal milestones was 0.0 months (95% confidence interval [CI]: −0.8; 0.8), and for hospital-diagnosed AD, it was −0.3 months (95% CI: −5.4; 4.8). For boys, the average age difference was 0.1 months (95% CI: −0.6; 0.9) and −0.3 months (95% CI: −3.6; 3.0), respectively.

Limitations

No information on treatment was available. Missing data on covariates (<5%) were not addressed.

Conclusion

No association was found between AD and puberty in either girls or boys.

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儿童和青春期发育中的特应性皮炎：一项全国性队列研究。

背景：特应性皮炎（AD）可能延迟青春期，但缺乏相关研究。目的：探讨AD与青春期的关系。方法：丹麦国家出生队列中的一个亚队列包括2000年至2003年出生的儿童，母亲报告在6个月，18个月和7岁时被医生诊断为AD。国家患者登记处确定了医院诊断的AD。从11岁开始，孩子们每半年提供一次关于青春期发展的信息。我们使用区间剔除回归模型估计了达到Tanner阶段1到5的平均年龄差异，以及腋毛、痤疮、第一次射精、声音破裂和月经初潮年龄的发展。结果：共有15,534名儿童参与，21.5%的儿童自述患有医生诊断的AD， 0.7%的儿童患有医院诊断的AD。对于自我报告医生诊断为AD的女孩，达到所有青春期里程碑的平均年龄差为0.0个月(95%置信区间[CI]: -0.8；0.8个月)，对于医院诊断的AD，为-0.3个月(95% CI: -5.4；4.8)。男孩的平均年龄差异为0.1个月(95% CI: -0.6；0.9)和-0.3个月(95% CI: -3.6；分别为3.0)。局限性：没有关于治疗的信息。缺少协变量数据(结论：在女孩或男孩中，AD与青春期没有关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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