Atopic dermatitis in childhood and pubertal development: A nationwide cohort study

JAAD International Pub Date : 2024-11-21 DOI:10.1016/j.jdin.2024.09.018

Camilla Lomholt Kjersgaard MD , Andreas Ernst MD, PhD , Pernille Jul Clemmensen MD, PhD , Lea Lykke Harrits Lunddorf MD, PhD , Linn Håkonsen Arendt MD, PhD , Nis Brix MD, PhD , Onyebuchi A. Arah MD, PhD , Mette Deleuran MD, PhD , Cecilia Høst Ramlau-Hansen MHSc, PhD

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Abstract

Background

Atopic dermatitis (AD) might delay puberty, but research is lacking.

Objective

To investigate the association between AD and puberty.

Methods

A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at 6 months, 18 months, and 7 years old. The National Patient Registry identified hospital-diagnosed AD. From 11 years, the children give half-yearly information on pubertal development. We estimated the mean age difference in months at attaining Tanner stages 1 to 5 and the development of axillary hair, acne, first ejaculation, voice break, and age at menarche, using an interval-censored regression model.

Results

In total, 15,534 children participated, 21.5% had self-reported doctor-diagnosed AD and 0.7% had hospital-diagnosed AD. For girls with self-reported doctor-diagnosed AD, the average age difference at reaching all pubertal milestones was 0.0 months (95% confidence interval [CI]: −0.8; 0.8), and for hospital-diagnosed AD, it was −0.3 months (95% CI: −5.4; 4.8). For boys, the average age difference was 0.1 months (95% CI: −0.6; 0.9) and −0.3 months (95% CI: −3.6; 3.0), respectively.