Functionally specialized spectral organization of the resting human cortex

Abstract

Ample studies across various neuroimaging modalities have suggested that the human cortex at rest is hierarchically organized along the spectral and functional axes. However, the relationship between the spectral and functional organizations of the human cortex remains largely unexplored. Here, we reveal the confluence of functional and spectral cortical organizations by examining the functional specialization in spectral gradients of the cortex. These spectral gradients, derived from functional magnetic resonance imaging data at rest using our temporal de-correlation method to enhance spectral resolution, demonstrate regional frequency biases. The grading of spectral gradients across the cortex – aligns with many existing brain maps – is found to be highly functionally specialized through discovered frequency-specific resting-state functional networks, functionally distinctive spectral profiles, and an intrinsic coordinate system that is functionally specialized. By demonstrating the functionally specialized spectral gradients of the cortex, we shed light on the close relation between functional and spectral organizations of the resting human cortex.