Increased epicardial adipose tissue volume may adversely affect outcomes in patients undergoing transcatheter aortic valve implantation.

IF 1.4 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Postepy W Kardiologii Interwencyjnej Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI:10.5114/aic.2024.142574

Kerem Özbek, Mustafa Dağlı, Ahmet Balun, Murat M Yigitbasi, Zehra G Çetin, Bekir Demirtaş, Eren Çamur, Mustafa Çetin, Hülya Çiçekçioğlu

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Abstract

Introduction: Epicardial adipose tissue (EAT) influences the development of cardiovascular diseases through the secretion of inflammatory cytokines. Transcatheter aortic valve implantation (TAVI) is one of the most commonly used methods for treating severe aortic stenosis in adults.

Aim: Given the role of inflammatory cytokines in the progression of aortic stenosis, we investigated the impact of EAT on the outcomes of patients undergoing TAVI.

Material and methods: The medical records of 334 patients who underwent TAVI for symptomatic severe aortic stenosis between March 2018 and December 2022 were evaluated after applying the exclusion criteria. Major adverse cardiac and cerebrovascular endpoints (MACCE) were defined according to the Valvular Academic Research Consortium criteria. The patients were divided into two groups: those with and without MACCE.

Results: Mean EAT volume was higher in patients with MACCE than those without MACCE (120.7 ±43.9 vs. 96.1 ±39.8, p < 0.001). Univariate Cox proportional-risk analysis revealed that creatinine and albumin levels, mean systolic pulmonary artery pressure, and EAT volume were significantly associated with MACCE. Multivariate Cox proportional-hazard analysis showed that EAT volume (hazard ratio (HR) = 1.012; 95% confidence interval (CI): 1.006-1.018; p < 0.001) and albumin level (HR = 0.925; 95% CI: 0.866-0.987; p = 0.018) were significantly independently associated with MACCE.

Conclusions: The EAT volume and 1-year outcomes may be related in patients undergoing TAVI for severe aortic stenosis.

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心外膜脂肪组织体积增加可能对经导管主动脉瓣植入术患者的预后产生不利影响。

心外膜脂肪组织（EAT）通过分泌炎性细胞因子影响心血管疾病的发生。经导管主动脉瓣植入术（TAVI）是治疗成人严重主动脉瓣狭窄最常用的方法之一。目的：考虑到炎症因子在主动脉狭窄进展中的作用，我们研究了EAT对TAVI患者预后的影响。材料与方法：采用排除标准，对2018年3月至2022年12月期间334例因症状性重度主动脉瓣狭窄行TAVI的患者病历进行评估。主要不良心脑血管终点（MACCE）根据瓣膜学术研究联盟标准定义。患者分为两组：有MACCE和无MACCE。结果：MACCE患者的平均EAT体积高于无MACCE患者（120.7±43.9比96.1±39.8,p < 0.001）。单因素Cox比例风险分析显示，肌酐和白蛋白水平、平均肺动脉收缩压和EAT体积与MACCE显著相关。多因素Cox比例风险分析结果显示，EAT体积(风险比(HR) = 1.012；95%置信区间（CI）： 1.006-1.018；p < 0.001)和白蛋白水平(HR = 0.925；95% ci: 0.866-0.987；p = 0.018)与MACCE显著独立相关。结论：严重主动脉瓣狭窄患者接受TAVI治疗时，EAT容量和1年预后可能相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Postepy W Kardiologii Interwencyjnej 医学-心血管系统

CiteScore

1.60

自引率

15.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Postępy w Kardiologii Interwencyjnej/Advances in Interventional Cardiology is indexed in: Index Copernicus, Ministry of Science and Higher Education Index (MNiSW). Advances in Interventional Cardiology is a quarterly aimed at specialists, mainly at cardiologists and cardiosurgeons. Official journal of the Association on Cardiovascular Interventions of the Polish Cardiac Society.