On the use of sham transcutaneous spinal cord stimulation in spinal cord injury clinical trials

IF 11.7 1区 医学 Q1 CLINICAL NEUROLOGY Brain Pub Date : 2025-01-31 DOI:10.1093/brain/awaf040
John L K Kramer, Tania Lam, Fabio Rossi, Judy Illes
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Abstract

Kramer et al. examine the reasons put forth by investigators for excluding a sham condition in trials of neuromodulation therapies for individuals with spinal cord injury. They conclude that current dogma does not justify this design, and emphasize the need for future trials to include appropriate controls.
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假性经皮脊髓刺激在脊髓损伤临床试验中的应用
Kramer等人研究了研究者提出的在脊髓损伤患者的神经调节疗法试验中排除假性疾病的原因。他们的结论是,目前的理论不能证明这种设计是合理的,并强调未来的试验需要包括适当的控制。
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来源期刊
Brain
Brain 医学-临床神经学
CiteScore
20.30
自引率
4.10%
发文量
458
审稿时长
3-6 weeks
期刊介绍: Brain, a journal focused on clinical neurology and translational neuroscience, has been publishing landmark papers since 1878. The journal aims to expand its scope by including studies that shed light on disease mechanisms and conducting innovative clinical trials for brain disorders. With a wide range of topics covered, the Editorial Board represents the international readership and diverse coverage of the journal. Accepted articles are promptly posted online, typically within a few weeks of acceptance. As of 2022, Brain holds an impressive impact factor of 14.5, according to the Journal Citation Reports.
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