Glass-Facilitated Thermal Decomposition of Difluoromethoxy Arenes

IF 3.1 3区化学 Q2 CHEMISTRY, APPLIED Organic Process Research & Development Pub Date : 2025-02-04 DOI:10.1021/acs.oprd.4c00490

Sirun Yang, Tianhua Tang, Hayden Cheek, Joseph J. Topczewski, Eric Wiensch, Daniel J. Valco

引用次数: 0

Abstract

This report describes a comprehensive differential scanning calorimetry (DSC) evaluation of difluoromethoxy-containing aromatic building blocks. Central to this evaluation is a comparison between DSC thermograms obtained in a glass capillary and those obtained in a gold-plated crucible. The decomposition of difluoromethoxybenzene is shown to be autocatalytic in a glass capillary. A diverse series of difluoromethoxy arenes were evaluated, and most exhibited dichotomous, vessel-dependent decomposition. This distinction raises concerns about glass-facilitated thermal decomposition and safety concerns regarding materials of reactor construction. This study underscores the importance of reactive chemistry evaluations in the development of new fluorinated chemicals, especially when using glass equipment.

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.