{"title":"Enantioselective Synthesis of Oxa-Spirosilanes via Dual Dehydrogenative Silylation of C(sp3)–H Bonds Catalyzed by Chiral Pincer Iridium Complexes","authors":"Sifan Liu, Zichen Wang, Sihan Peng, Guixia Liu* and Zheng Huang*, ","doi":"10.1021/acs.organomet.4c00456","DOIUrl":null,"url":null,"abstract":"<p >A series of chiral pincer iridium complexes supported by oxazoline-containing P<sup>C</sup>CN-type ligands were synthesized. Among them, the (<sup><i>t</i>Bu</sup>P<sup>C</sup>CN<sup><i>t</i>Bu</sup>)IrHCl complex bearing sterically bulky <i>t</i>Bu groups both at the P atom and on the oxazoline ring exhibits high efficiency and enantioselectivity for the asymmetric dual dehydrogenative silylation of C(sp<sup>3</sup>)–H bonds. This reaction provides an enantioselective approach to oxa-spirosilanes with a stereogenic silicon center from readily available diarylsilanes.</p>","PeriodicalId":56,"journal":{"name":"Organometallics","volume":"44 1","pages":"3–7 3–7"},"PeriodicalIF":2.9000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organometallics","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.organomet.4c00456","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
A series of chiral pincer iridium complexes supported by oxazoline-containing PCCN-type ligands were synthesized. Among them, the (tBuPCCNtBu)IrHCl complex bearing sterically bulky tBu groups both at the P atom and on the oxazoline ring exhibits high efficiency and enantioselectivity for the asymmetric dual dehydrogenative silylation of C(sp3)–H bonds. This reaction provides an enantioselective approach to oxa-spirosilanes with a stereogenic silicon center from readily available diarylsilanes.
期刊介绍：
Organometallics is the flagship journal of organometallic chemistry and records progress in one of the most active fields of science, bridging organic and inorganic chemistry. The journal publishes Articles, Communications, Reviews, and Tutorials (instructional overviews) that depict research on the synthesis, structure, bonding, chemical reactivity, and reaction mechanisms for a variety of applications, including catalyst design and catalytic processes; main-group, transition-metal, and lanthanide and actinide metal chemistry; synthetic aspects of polymer science and materials science; and bioorganometallic chemistry.
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