P-35 CLINICAL AND EPIDEMIOLOGICAL DIFFERENCES BETWEEN PATIENTS MONOINFECTED WITH HEPATITIS B AND COINFECTED WITH HEPATITIS DELTA IN A HYPERENDEMIC REGION OF HEPATITIS B

IF 4.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Annals of hepatology Pub Date : 2024-12-01 Epub Date: 2024-12-06 DOI:10.1016/j.aohep.2024.101649

Walter Silva Junior Junior , Jadson Dourado Costa , Ingrid Laise Vivas , Sidelcina Rugieri Pacheco , Ezequiel Ridruejo , Juan Salcedo , Deusilene Souza Dallacqua , Raymundo Paraná , Maria Izabel Schinoni

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Abstract

Conflict of interest

Introduction and Objectives

Hepatitis B and co-infection with hepatitis delta are viral liver diseases that can rapidly progress to cirrhosis and hepatocellular carcinoma (HCC). Objectives: To compare the epidemiological profile between patients mono-infected with hepatitis B and patients co-infected with hepatitis B and delta in a hyperendemic region.

Patients / Materials and Methods

A cross-sectional and historical cohort study analyzing 286 medical records of co-infected individuals and 649 medical records of mono-infected. Variables: sex, age, stage of liver fibrosis, levels of liver enzymes, albumin, platelets, alpha-fetoprotein, presence of HCC, and outcomes (liver transplant or death).

Results and Discussion

Of the 286 co-infected, 189 (70.5%) were male, mean age 56 ± 19. About stage of fibrosis, 97 (34%) had no fibrosis, 163 (57%) had (F1F3), and 26 (9%) had cirrhosis (F4). Mean GGT were 64.6 ± 86.6 U/L, ALT 36.2 ± 33.1 U/L, AST 41.2 ± 61.1 U/L, albumin 4.1 ± 0.75 g/dL, platelets 192 ± 77 thousand/mm³, alpha-fetoprotein 122.7 ± 181.1 ng/mL. 12 (4.2%) developed HCC, mean age of 53 ± 11.8; 8 (2.8%) underwent liver transplantation, and 22 (7.7%) died. Of the 659 mono-infected, 449 (68.14%) were male, mean age 53 ± 12.7. About stage of fibrosis, 248 (36%) had no fibrosis, 335 (48.69%) had fibrosis (F1F3), and 105 (15.26%) had cirrhosis (F4). Mean GGT were 64.4 ± 85.9 U/L, ALT 36.2 ± 33.8 U/L, AST 40.7 ± 59.9 U/L, albumin 4.19 ± 0.74 g/dL, platelets 3.27 ± 3.4 thousand/mm³, alpha-fetoprotein 117.6 ± 2133.5 ng/mL. 31 (4.7%) developed HCC, mean age of 57.4 ± 12.6; 18 (2.7%) died.

Conclusions

Co-infected patients have a higher prevalence of liver fibrosis and develop HCC at a younger age. There was statistical significance in platelet count, indicating greater severity of liver dysfunction in the mono-infected group.

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乙型肝炎高流行区乙型肝炎单感染与丁型肝炎合并感染患者的临床和流行病学差异

利益冲突介绍和目的乙型肝炎和合并丁型肝炎是病毒性肝病，可迅速发展为肝硬化和肝细胞癌（HCC）。目的：比较某高流行地区乙型肝炎单一感染患者与乙型肝炎和丁型肝炎合并感染患者的流行病学特征。患者/材料与方法横断面和历史队列研究，分析286例合并感染病例和649例单独感染病例。变量：性别、年龄、肝纤维化分期、肝酶、白蛋白、血小板、甲胎蛋白水平、肝细胞癌的存在和结局（肝移植或死亡）。结果与讨论286例合并感染病例中，男性189例（70.5%），平均年龄56±19岁。在纤维化分期方面，无纤维化97例（34%），F1F3型163例（57%），肝硬化26例（9%）。平均GGT为64.6±86.6 U/L， ALT为36.2±33.1 U/L， AST为41.2±61.1 U/L，白蛋白为4.1±0.75 g/dL，血小板为192±7.7千/mm³，甲胎蛋白为122.7±181.1 ng/mL。12例（4.2%）发生HCC，平均年龄53±11.8岁；8例（2.8%）行肝移植，22例（7.7%）死亡。659例单感染者中，男性449例（68.14%），平均年龄（53±12.7）岁。在纤维化分期方面，无纤维化248例（36%），纤维化335例（48.69%）（F1F3），肝硬化105例（15.26%）（F4）。平均GGT为64.4±85.9 U/L， ALT为36.2±33.8 U/L， AST为40.7±59.9 U/L，白蛋白为4.19±0.74 g/dL，血小板为3.27±3.4千/mm³，甲胎蛋白为117.6±2133.5 ng/mL。31例（4.7%）发生HCC，平均年龄57.4±12.6岁；死亡18例（2.7%）。结论sco感染患者肝纤维化发生率较高，HCC发病年龄较轻。血小板计数差异有统计学意义，提示单感染组肝功能障碍更严重。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.