P-44 LONG-TERM SURVIVAL IN PATIENTS WITH LIVER TRANSPLANTATION

Abstract

Conflict of interest

No

Introduction and Objectives

Background: Liver transplant is the only effective treatment for acute or chronic liver diseases in the terminal stage. With advances in the management of immunosuppression and surgical techniques, survival is high, but it can decrease for different reasons depending on the time of evolution of the transplant. Aim: Determine long-term survival in patients with liver transplants and the main causes of mortality.

Patients / Materials and Methods

Methods: It is a descriptive, retrospective study in patients with liver transplant from a cadaveric donor, carried out at the Medical Surgical Research Center between 1999 and 2019, 117 patients with one year or more of survival were included. The main variables were causes of mortality and survival at 5, 10, 15 and 20 years, overall and by indication of the transplant (grouped into cirrhosis due to hepatitis B and C viruses, due to alcohol, autoimmune and other etiologies), which were obtained from the Liver Transplant Database. For the statistical analysis, summary measures were used according to the type of variable and the Kaplan Meier method for survival analysis.

Results and Discussion

Results: Of the 117 patients, 69 had died as of June 2024. Overall survival was 74.4%, 58.4%. 37.5% and 27.5% at 5, 10, 15 and 20 years respectively, with an overall mean of 13 years (95% CI 11.3-14.5), in relation to survival related to the etiology of the transplant the average was 9.3 years for viral cirrhosis, 9.9 for alcoholic etiology, 14.3 for autoimmune, and 15.8 years for others. The most frequent causes of long-term mortality were recurrence of the primary disease (20.5%) with a predominance of hepatitis C virus and de novo tumors (11.1%).

Conclusions

The mean long-term overall survival in patients with liver transplantation was greater than 10 years, with a negative impact of cirrhosis due to viruses and alcohol as an indication for transplant.