P-45 ANALYSIS OF SURVIVAL RATE AND FACTORS ASSOCIATED WITH LIVER RETRANSPLANTATION: 18-YEAR EXPERIENCE IN BOGOTÁ - COLOMBIA

Abstract

Conflict of interest

No

Introduction and Objectives

Liver retransplantation is the only therapeutic option for irreversible hepatic graft failure, this situation raises ethical and practical issues, due to the diminished survival of the second graft and the disparity between the number of liver donors and potential recipients in Colombia. To compare first and third year survival between patients with a single liver transplant and those who have undergone liver retransplantation

Patients / Materials and Methods

Analytical observational study of a retrospective cohort patients with liver transplant and retransplant (over 18 years old) at the Cardioinfantil Foundation between December 2005 and December 2023. The associated factors that together explain liver retransplantation, the Cox regression model with constant time and the negative log binomial model will be used. The analysis will be performed using R software. The survival analysis of patients with liver transplant and retransplantation will be performed using the Kaplan Meier method. All statistical tests will be evaluated with a significance level of 5% (p < 0.05).

Results and Discussion

Between 2005 and 2023, 689 liver transplants were performed in adult patients at our hospital, 39 of which (5.6%) were liver retransplantation. The first year retransplant survival was 83.3% and the third year 72.2%, compared with the first year transplant survival 86.1% and the third year 82%. Of the 39 retransplant cases 21 cases (53.8%) were early (< 6 months) while 18 cases (46.1%) were late (> 6 months). Regarding the causes that led to early liver retransplantation, the most frequent was arterial thrombosis 13 (33.3%) cases, followed by primary graft dysfunction 6 cases (15.3%). For late retransplantation the most frequent cause was chronic cellular rejection 7 cases (17.9%) followed by recurrence of the primary disease 3 cases (7.6%).

Conclusions

the present study, liver retransplantation is a safe treatment option with mortality compared to liver transplantation and our results do not differ from the global epidemiology.