Lipoprotein(a): Screening and Care of the High-Risk Cardiovascular Disease Patient

Elizabeth Matthews, Pamela Biernacki
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Abstract

Despite rigorous efforts to mitigate comorbidities contributing to cardiovascular events, the prevalence of heart disease continues to rise. This report highlights the role of lipoprotein (Lp)(a) a low-density lipoprotein, as a causal risk factor for cardiovascular disease. The impact of Lp(a) on heart disease has been well established, and testing is widely available; yet, screening for Lp(a) continues to be underperformed. The role of Lp(a) in the development of cardiovascular diseases as well as the clinical guidelines for screening patients in primary and secondary prevention populations are reviewed. Finally, clinical practice strategies for patients with elevated Lp(a) are presented.
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脂蛋白(a):高危心血管疾病患者的筛查和护理
尽管采取了严格的措施来减轻导致心血管事件的合并症,但心脏病的患病率仍在继续上升。本报告强调了脂蛋白(Lp)(a)(低密度脂蛋白)作为心血管疾病的因果危险因素的作用。Lp(a)对心脏病的影响已得到充分证实,检测方法也很广泛;然而,对Lp(a)的筛查仍然表现不佳。本文综述了Lp(a)在心血管疾病发展中的作用以及在一级和二级预防人群中筛查患者的临床指南。最后,提出了Lp(a)升高患者的临床实践策略。
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