New route to preparation of loxoprofen through Mizoroki-Heck reaction as the key step

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC Synthetic Communications Pub Date : 2025-02-01 DOI:10.1080/00397911.2024.2441331

Huansheng Chen , Dandan Tang , Long Lin , Wei Yuan , Yu Chen , Xianhua Pan

引用次数: 0

Abstract

The current study describes a new preparation of loxoprofen. The whole process includes five steps from cheap cyclopentanone and methyl 4-bromophenylacetate as the starting materials. The key intermediate is obtained through Mizoroki-Heck reaction of 2-methylenecyclopentanone and methyl 2-(4-bromophenyl)propanoate. The desired loxoprofen is yielded through hydrogenation followed by hydrolysis in 56% overall yield with 99.7% purity.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.

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