{"title":"Localized Hepatoblastoma in a Patient with Trisomy 18 Achieved Complete Remission with Radiation Therapy Alone","authors":"S. Chafe , M. Rojas , J. Zebak","doi":"10.1016/j.ijrobp.2024.11.060","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Case report observing the response to palliative radiation therapy in a 19 month old with hepatoblastoma, Trisomy 18 and multiple comorbidities.</div></div><div><h3>Methods</h3><div>Radiation was delivered to the Liver mass. 3000 cGy was delivered in 10 daily fractions over 2 weeks.</div></div><div><h3>Results</h3><div>Complete resolution of the mass and AFP normalized by 4 months. The patient remains in remission 5 years post end of treatment.</div></div><div><h3>Conclusion</h3><div>Radiation should be a considered for patients with Hepatoblastoma who are not candidates for surgical resection and/or chemotherapy</div></div>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 3","pages":"Page e17"},"PeriodicalIF":6.4000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Oncology Biology Physics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0360301624036344","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives
Case report observing the response to palliative radiation therapy in a 19 month old with hepatoblastoma, Trisomy 18 and multiple comorbidities.
Methods
Radiation was delivered to the Liver mass. 3000 cGy was delivered in 10 daily fractions over 2 weeks.
Results
Complete resolution of the mass and AFP normalized by 4 months. The patient remains in remission 5 years post end of treatment.
Conclusion
Radiation should be a considered for patients with Hepatoblastoma who are not candidates for surgical resection and/or chemotherapy
期刊介绍：
International Journal of Radiation Oncology • Biology • Physics (IJROBP), known in the field as the Red Journal, publishes original laboratory and clinical investigations related to radiation oncology, radiation biology, medical physics, and both education and health policy as it relates to the field.
This journal has a particular interest in original contributions of the following types: prospective clinical trials, outcomes research, and large database interrogation. In addition, it seeks reports of high-impact innovations in single or combined modality treatment, tumor sensitization, normal tissue protection (including both precision avoidance and pharmacologic means), brachytherapy, particle irradiation, and cancer imaging. Technical advances related to dosimetry and conformal radiation treatment planning are of interest, as are basic science studies investigating tumor physiology and the molecular biology underlying cancer and normal tissue radiation response.
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