The beneficial effects of the herbal medicine Di-Huang-Yin-Zi on patients with traumatic cauda equina injury: A randomized, double-blind, placebo-controlled study

Abstract

Objective

This study aimed to investigate the safety and efficacy of Di-Huang-Yin-Zi (DHYZ), also known as Rehmanniae Yin-Zi, a traditional Chinese medicinal formula used for treating of neurological disorders in patients with traumatic cauda equina injury (TCEI).

Methods

In this double-blind, placebo-controlled study, TCEI patients with American Spinal Injury Association (ASIA) impairment grades C were randomized to receive either DHYZ (n = 30) or placebo (n = 30) for 8 weeks. Both groups also received rehabilitation therapy and oral mecobalamine therapy during the treatment. Motor and sensory functions, as well as walking ability, were assessed biweekly.

Results

At the end of the treatment, the DHYZ group exhibited significantly higher scores in sensory and motor function, as well as walking ability, compared to the placebo group (all P < 0.05). Additionally, no serious side effects were reported.

Conclusion

DHYZ has the potential to accelerate nerve repair and may serve as an effective adjuvant therapy to enhance the recovery of nerve function in patients with TCEI.