Association between sleep disorders and subsequent heart failure

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS IJC Heart and Vasculature Pub Date : 2025-04-01 Epub Date: 2025-01-25 DOI:10.1016/j.ijcha.2025.101618

Jamschid Sedighi , Mark Luedde , Julia Gaensbacher-Kunzendorf , Hans-Joerg Hippe , Pascal Bauer , Birgit Assmus , Samuel Sossalla , Karel Kostev

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Abstract

Background

Sleep disorders are prevalent conditions that may influence the progression of various heart diseases. However, the relationship between sleep disorders and the onset of heart failure (HF) remains unclear.

Objective

The purpose of this study was to investigate whether sleep disorders are associated with an increased risk of developing HF.

Methods

We conducted a retrospective cohort study using data from 1,293 general practices across Germany sourced from the IQVIA Disease Analyzer database. The study included patients with an initial diagnosis of HF (ICD-10 code: I50) between January 2010 and December 2022 (index data) These patients were matched with control subjects without HF based on age, sex, and pre-existing conditions. The primary outcome was the association between prior sleep disorder diagnoses and the subsequent development of HF. Data were available for 9,345,246 individuals, of which 406,265 had a history of HF.

Results

The study analyzed data from 123,516 patients with HF and an equal number of matched controls. The mean age of participants was 73.3–73.4 (SD 12.4) years, with 53.2% being women. Sleep disorders diagnosed prior to the onset of HF were significantly associated with an increased risk of developing HF. This association was consistent across different types of sleep disorders overall (OR: 1.22; 95%CI: 1.19–1.24) as well as insomnia (OR: 1.26; 95%CI: 1.21–1.31), sleep apnea (OR: 1.20; 95%CI: 1.15–1.25), and unspecified sleep disorders (OR: 1.21; 95%CI: 1.18–1.25).

Conclusion

In this large cohort of outpatients, a prior diagnosis of sleep disorders was linked to a higher incidence of HF. These findings suggest that sleep disorders may serve as a risk factor for the development of HF, highlighting the need for early identification and management of sleep disturbances in at-risk populations. Addressing these disorders in clinical practice could represent a pivotal step towards better cardiovascular health and patient care.

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睡眠障碍与随后的心力衰竭之间的关系

背景：睡眠障碍是可能影响各种心脏疾病进展的普遍状况。然而，睡眠障碍与心力衰竭（HF）发病之间的关系尚不清楚。目的本研究的目的是探讨睡眠障碍是否与心衰风险增加有关。方法：我们进行了一项回顾性队列研究，使用了来自IQVIA疾病分析数据库的德国1293个全科医生的数据。该研究纳入了2010年1月至2022年12月期间首次诊断为HF （ICD-10代码：I50）的患者（指数数据），这些患者根据年龄、性别和既往疾病与无HF的对照组进行匹配。主要结局是先前睡眠障碍诊断与随后HF发展之间的关系。9345246人，其中406265人有心衰病史。结果：该研究分析了123516例心衰患者和同等数量的匹配对照组的数据。参与者的平均年龄为73.3-73.4岁（SD 12.4），其中53.2%为女性。在HF发病前诊断出的睡眠障碍与发展为HF的风险增加显著相关。这种关联在不同类型的睡眠障碍中总体上是一致的(OR: 1.22；95%CI: 1.19-1.24)以及失眠(OR: 1.26；95%CI: 1.21-1.31)，睡眠呼吸暂停(OR: 1.20；95%CI: 1.15-1.25)和未指明的睡眠障碍(OR: 1.21；95%置信区间:1.18—-1.25)。结论：在这一大群门诊患者中，先前的睡眠障碍诊断与HF的高发病率有关。这些发现表明，睡眠障碍可能是心衰发展的一个危险因素，强调了在高危人群中早期识别和管理睡眠障碍的必要性。在临床实践中解决这些疾病可能是朝着更好的心血管健康和患者护理迈出的关键一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.