Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells

IF 3.5 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING Regenerative Therapy Pub Date : 2025-03-01 Epub Date: 2024-12-06 DOI:10.1016/j.reth.2024.11.019

Yu Zhang , Yueda Lu , Xinyue Hu , Mengxing Jiang , Zhixiu Chen , Lingkun Jin , Min Li , Chen Chen , Jianye Wang

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Abstract

Human umbilical cord blood mononuclear cells (hUCB-MNCs) are a population of cells derived from neonatal cord blood, encompassing various stem cells and immune cells. The unique characteristics of hUCB-MNCs endow them with distinctive multifunctionality, including the promotion of angiogenesis, acceleration of tissue repair, regulation of immune responses, neuroprotection, alleviation of inflammatory reactions, enhancement of antioxidant capacity, reduction of fibrosis processes, and inhibition of apoptosis. These diverse biological properties underscore the significant clinical therapeutic potential of hUCB-MNCs, which are widely applied in the treatment of various diseases. This review aims to summarize the underlying mechanisms responsible for the multifunctional attributes of hUCB-MNCs, elucidating their potential modes of action in disease management and providing novel theoretical insights and practical guidance for their expanded application across different disease domains. By synthesizing current research findings, this review may provide insights into the potential clinical applications of hUCB-MNCs in the fields of regenerative medicine and cell therapy.

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人脐带血单个核细胞的功能特征及治疗潜力

人脐带血单核细胞（hUCB-MNCs）是从新生儿脐带血中提取的细胞群，包括各种干细胞和免疫细胞。hUCB-MNCs的独特特性赋予其独特的多功能性，包括促进血管生成、加速组织修复、调节免疫反应、神经保护、减轻炎症反应、增强抗氧化能力、减少纤维化过程和抑制细胞凋亡。这些不同的生物学特性强调了hub - mncs的重要临床治疗潜力，它被广泛应用于各种疾病的治疗。本文旨在总结hub - mncs多功能属性的潜在机制，阐明其在疾病管理中的潜在作用模式，并为其在不同疾病领域的扩展应用提供新的理论见解和实践指导。通过综合目前的研究成果，本文综述了hub - mncs在再生医学和细胞治疗领域的潜在临床应用。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.