{"title":"Cefotetan: antibacterial activity against Staphylococcus aureus in the presence of human serum.","authors":"J R Edwards","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Cefotetan is a broad spectrum cephamycin antibiotic with a long serum half-life (3-4.5 h): this is explained, in part, by serum-protein-binding (SPB) of 88%. The rate of kill of Staphylococcus aureus by cefotetan was assessed in human serum or broth containing reducing concentrations of drug simulating those seen following a 1 g intravenous dose to man. Cefotetan was bactericidal in serum despite the assumed concentration of unbound drug never reaching the minimum inhibitory concentration (MIC) for the test strain. In a separate study, ceftriaxone (SPB 96%) was more active in broth (MIC 4 mg/1) than cefotetan (MIC 16 mg/1). In 100% serum the minimum bactericidal concentration (MBC) of ceftriaxone was 64 mg/1 whilst the MBC for cefotetan was 16 mg/1.</p>","PeriodicalId":9733,"journal":{"name":"Chemioterapia : international journal of the Mediterranean Society of Chemotherapy","volume":"7 4","pages":"271-3"},"PeriodicalIF":0.0000,"publicationDate":"1988-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemioterapia : international journal of the Mediterranean Society of Chemotherapy","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Cefotetan is a broad spectrum cephamycin antibiotic with a long serum half-life (3-4.5 h): this is explained, in part, by serum-protein-binding (SPB) of 88%. The rate of kill of Staphylococcus aureus by cefotetan was assessed in human serum or broth containing reducing concentrations of drug simulating those seen following a 1 g intravenous dose to man. Cefotetan was bactericidal in serum despite the assumed concentration of unbound drug never reaching the minimum inhibitory concentration (MIC) for the test strain. In a separate study, ceftriaxone (SPB 96%) was more active in broth (MIC 4 mg/1) than cefotetan (MIC 16 mg/1). In 100% serum the minimum bactericidal concentration (MBC) of ceftriaxone was 64 mg/1 whilst the MBC for cefotetan was 16 mg/1.