Synergistic Delivery of Paclitaxel-Coated ZIF-8 Metal-Organic Framework Nanoparticles for Enhanced in Vitro Administration in Liver Cancer Cell Lines

IF 2.7 4区 化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Journal of Cluster Science Pub Date : 2025-02-02 DOI:10.1007/s10876-024-02739-1
Xinhua Zhao, Xiaoyong Wu, Liqin Ruan, Weili Chen, Ningbo Fang, Zhaoping Wu, Hechun Liu, Jianhua Deng
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Abstract

Liver cancer is a major global health challenge, ranking as the third leading cause of cancer-related deaths worldwide. In this study, we explore the use of paclitaxel-coated ZIF-8 metal-organic framework nanoparticles (ZIF-8 NPs/Pacx) as a novel drug delivery system for enhanced liver cancer treatment. A comprehensive set of analyses, including morphology evaluation, particle size distribution, zeta potential measurement, drug loading capacity, encapsulation efficiency, stability, and In vitro drug release behavior, was conducted to assess the nanoparticles’ performance. The ZIF-8 NPs/Pacx demonstrated significant antitumor activity at a concentration of 75 µg/mL, particularly against HepG2 and Hep3B liver cancer cell lines. RT-PCR analysis revealed that ZIF-8 NPs/Pacx stimulated TNF-α expression in HepG2, Hep3B, and normal liver cells (NLCs), with further confirmation through Western blot analysis of TNF-α and β-actin levels. Notably, the nanoparticles exhibited the ability to inhibit cell proliferation and induce apoptosis in liver cancer cells. These findings suggest that ZIF-8 NPs/Pacx could offer an innovative approach for the delivery of paclitaxel to liver cancer cells, maximising treatment effectiveness with minimal side effects, and positioning this system as a promising candidate for future liver cancer treatments.

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来源期刊
Journal of Cluster Science
Journal of Cluster Science 化学-无机化学与核化学
CiteScore
6.70
自引率
0.00%
发文量
166
审稿时长
3 months
期刊介绍: The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.
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