Yolk–shell Au@carbon nanospheres with photothermal and electron-plunder sterilization for infected wound healing

IF 7.4 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Science China Materials Pub Date : 2024-12-18 DOI:10.1007/s40843-024-3151-8

Jin Chai (, ), Changzhen Qu (, ), Kunpeng Li (, ), Jiaheng Liang (, ), Qian Zhou (, ), Rong Zhuang (, ), Shuo Wang (, ), Fei Xu (, ), Qingyan Jia (, ), Peng Li (, )

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Abstract

Highly pathogenic-resistant bacteria infections seriously hinder the wound healing process and induce a catastrophic threat to human health. Incorporating multiple antibacterial strategies into nanostructured materials has been verified to possess paramount promise for ameliorating therapeutic efficiency against resistant bacteria. Herein, a multifunctional yolk–shell nanocomposite (Au@HCN) comprised of an aurum (Au) core and hollow carbon nanosphere (HCN) shell was prepared via one-step copolymerization and carbonization. The electron plunder by Au@HCN on the bacterial membrane leads to bacterial membrane depolarization and enhanced reactive oxygen species (ROS) metabolism, resulting in remarkable efficacy against drug-resistant bacteria under dark conditions. Moreover, the synergetic photothermal therapy (PTT) displayed significant antibacterial properties (∼98%) when exposed to near-infrared (NIR) irradiation in vitro. Meanwhile, efficient eradication of drug-resistant bacteria in the infected wound in vivo was observed under NIR exposure, thereby promoting wound healing through the prominent antibacterial properties of Au@HCN. The yolk–shell Au@HCN possesses tremendous potential for combating multidrug resistance with high efficiency.

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蛋黄壳Au@carbon纳米球光热和电子掠夺消毒感染伤口愈合

高致病性耐药细菌感染严重阻碍伤口愈合过程，对人体健康造成灾难性威胁。将多种抗菌策略整合到纳米结构材料中已被证实具有改善耐药细菌治疗效率的最大希望。本文通过一步共聚和碳化制备了由金（Au）核和空心碳纳米球（HCN）壳组成的多功能蛋黄壳纳米复合材料（Au@HCN）。细菌膜上Au@HCN的电子掠夺导致细菌膜去极化，增强活性氧（ROS）代谢，从而在黑暗条件下对耐药菌产生显著的疗效。此外，协同光热疗法（PTT）在体外近红外（NIR）照射下显示出显著的抗菌性能（约98%）。同时，在近红外照射下观察到感染创面体内耐药菌的有效根除，从而通过Au@HCN突出的抗菌特性促进创面愈合。蛋黄壳Au@HCN具有高效对抗多药耐药的巨大潜力。

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来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.