{"title":"Cover Picture","authors":"","doi":"10.1002/cjoc.202590051","DOIUrl":null,"url":null,"abstract":"<p>We engineered a specialized actinomycete cell factory, 306A, optimized for the efficient production of PoTeMs. By introducing the heterologous biosynthetic gene cluster <i>fla</i> from marine-derived <i>Streptomyces flavogriseus</i> SCSIO 40032—akin to a factory receiving a production order—the biosynthetic machinery functions like an assembly line. Flavin oxidase and P450 enzymes function as key \"machines\" on this line, catalyzing the cyclization of PoTeMs precursors, hydroxylation, and the formation of a C14 ketone group, ultimately yielding mature PoTeMs such as 10-<i>epi</i>-xanthobaccin C. More details are discussed in the article by Zhang <i>et al</i>. on pages 483—490.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 5","pages":"473"},"PeriodicalIF":5.5000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.202590051","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cjoc.202590051","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
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Abstract
We engineered a specialized actinomycete cell factory, 306A, optimized for the efficient production of PoTeMs. By introducing the heterologous biosynthetic gene cluster fla from marine-derived Streptomyces flavogriseus SCSIO 40032—akin to a factory receiving a production order—the biosynthetic machinery functions like an assembly line. Flavin oxidase and P450 enzymes function as key "machines" on this line, catalyzing the cyclization of PoTeMs precursors, hydroxylation, and the formation of a C14 ketone group, ultimately yielding mature PoTeMs such as 10-epi-xanthobaccin C. More details are discussed in the article by Zhang et al. on pages 483—490.
期刊介绍：
The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.
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