Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease (Adv. Sci. 5/2025)

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Science Pub Date : 2025-02-04 DOI:10.1002/advs.202570027

Yuan Zhang, Cuiping Jia, Manli Guo, Qian Chen, Ying Wen, Ting Wang, Yinyin Xie, Xuejiao Fan, Jingwen Gao, Timur O. Yarovinsky, Renjing Liu, Zhiyong Jiang, Mengmeng Wang, Jin Zhou, Di Che, Lanyan Fu, Richard Edelson, Xiaoqiong Gu, John Hwa, Wai Ho Tang

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Abstract

Biomarker for Kawasaki Disease Vasculopathy

Platelet hyperreactivity is the hallmark of Kawasaki disease (KD). However, the role of platelet in KD vasculopathy remains elusive. Xiaoqiong Gu, John Hwa, Wai Ho Tang, and co-workers find that the direct interaction of platelet and monocyte promotes TGF 1 release and monocyte activation, resulting in the burst of inflammatory cytokines. The study provides the potential use of monocyte-platelet aggregates as a biomarker for KD vasculopathy. More details can be found in article number 2406282.

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血小板-单核细胞聚集引发川崎病的炎症和血管病变（Sci. 5/2025）

川崎病血管病变的生物标志物血小板高反应性是川崎病（KD）的标志。然而，血小板在KD血管病变中的作用仍然难以捉摸。顾晓琼，John Hwa， Wai Ho Tang等发现血小板与单核细胞的直接相互作用促进TGF 1的释放和单核细胞的活化，导致炎症细胞因子的爆发。该研究提供了单核细胞血小板聚集物作为KD血管病变生物标志物的潜在用途。更多的细节可以在2406282号文章中找到。

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.