Yuan Zhang, Cuiping Jia, Manli Guo, Qian Chen, Ying Wen, Ting Wang, Yinyin Xie, Xuejiao Fan, Jingwen Gao, Timur O. Yarovinsky, Renjing Liu, Zhiyong Jiang, Mengmeng Wang, Jin Zhou, Di Che, Lanyan Fu, Richard Edelson, Xiaoqiong Gu, John Hwa, Wai Ho Tang
{"title":"Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease (Adv. Sci. 5/2025)","authors":"Yuan Zhang, Cuiping Jia, Manli Guo, Qian Chen, Ying Wen, Ting Wang, Yinyin Xie, Xuejiao Fan, Jingwen Gao, Timur O. Yarovinsky, Renjing Liu, Zhiyong Jiang, Mengmeng Wang, Jin Zhou, Di Che, Lanyan Fu, Richard Edelson, Xiaoqiong Gu, John Hwa, Wai Ho Tang","doi":"10.1002/advs.202570027","DOIUrl":null,"url":null,"abstract":"<p><b>Biomarker for Kawasaki Disease Vasculopathy</b></p><p>Platelet hyperreactivity is the hallmark of Kawasaki disease (KD). However, the role of platelet in KD vasculopathy remains elusive. Xiaoqiong Gu, John Hwa, Wai Ho Tang, and co-workers find that the direct interaction of platelet and monocyte promotes TGF 1 release and monocyte activation, resulting in the burst of inflammatory cytokines. The study provides the potential use of monocyte-platelet aggregates as a biomarker for KD vasculopathy. More details can be found in article number 2406282.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 5","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570027","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570027","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Biomarker for Kawasaki Disease Vasculopathy
Platelet hyperreactivity is the hallmark of Kawasaki disease (KD). However, the role of platelet in KD vasculopathy remains elusive. Xiaoqiong Gu, John Hwa, Wai Ho Tang, and co-workers find that the direct interaction of platelet and monocyte promotes TGF 1 release and monocyte activation, resulting in the burst of inflammatory cytokines. The study provides the potential use of monocyte-platelet aggregates as a biomarker for KD vasculopathy. More details can be found in article number 2406282.
期刊介绍:
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.