Chengbin Liu, Qiwei Wang, Prof. Lili Shi, Prof. Tao Li
{"title":"Robust G-Quadruplex Dimer-Guided Transmembrane DNA Nanovehicles for Targeted Payload Delivery","authors":"Chengbin Liu, Qiwei Wang, Prof. Lili Shi, Prof. Tao Li","doi":"10.1002/anse.202400048","DOIUrl":null,"url":null,"abstract":"<p>Here we report a robust G-quadruplex (G4) dimer-guided transmembrane DNA nanovehicle for targeted payload delivery, based on dimeric G4-proximized aptamers that efficiently target transferrin receptors (TfR) over-expressed on cancer cell surface. It enables the cancer-specific delivery of fluorescent G4 ligands and therapeutic drugs for cellular imaging and treatment.</p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analysis & sensing","FirstCategoryId":"1085","ListUrlMain":"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/anse.202400048","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Here we report a robust G-quadruplex (G4) dimer-guided transmembrane DNA nanovehicle for targeted payload delivery, based on dimeric G4-proximized aptamers that efficiently target transferrin receptors (TfR) over-expressed on cancer cell surface. It enables the cancer-specific delivery of fluorescent G4 ligands and therapeutic drugs for cellular imaging and treatment.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
