Cover Feature: Applying Metallo-Organic Ligand Design Principles to the Stereoselective Synthesis of a Peptide-Based Pd2L4X4 Cage (ChemistryEurope 1/2025)

Abstract

The Cover Feature celebrates the stereoselective synthesis of a peptide-based palladium cage. The chiral, low-symmetry peptide-based ligand used to generate this Pd cage could theoretically yield up to four structural isomers. Remarkably, only a single isomeric cage is formed in solution, the thermodynamically stable one. The image represents the single isomer emerging into the spotlight from all the possible isomers, shown in different colours in the background. More information can be found in the Research Article by A. Palma and co-workers (DOI: 10.1002/ceur.202400050).