Adipogenic-Myogenic Signaling in Engineered Human Muscle Grafts used to Treat Volumetric Muscle Loss (Adv. Biology 12/2024)

Abstract

Tissue Engineered Muscle Grafts

Finding balance: Human myogenic progenitors grown on electrospun fibrin microfiber bundles stimulated skeletal muscle regeneration following volumetric muscle loss. The delivery of FAP-like ASCs requires optimization to increase muscle regeneration while minimizing the adipose tissue growth in vivo. More details can be found in article number 2400113 by Warren L. Grayson and co-workers.