{"title":"Front Cover: Factors Affecting Liquid-Liquid Phase Separation of RGG Peptides with DNA G-Quadruplex (ChemMedChem 2/2025)","authors":"Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi, Daisuke Miyoshi","doi":"10.1002/cmdc.202580201","DOIUrl":null,"url":null,"abstract":"<p>The front cover picture shows the critical role of arginine residues in G-quadruplex (G4) mediated liquid-liquid phase separation (LLPS). A visual representation shows an RGG peptide interacting with G4-DNA, forming LLPS droplets. The art highlights the importance of arginine′s specific interactions for LLPS, reflecting the study's insights into the molecular mechanisms driving G4-LLPS. More details can be found in article 10.1002/cmdc.202400460 by Daisuke Miyoshi and co-workers.<figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"20 2","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202580201","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemMedChem","FirstCategoryId":"3","ListUrlMain":"https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202580201","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
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Abstract
The front cover picture shows the critical role of arginine residues in G-quadruplex (G4) mediated liquid-liquid phase separation (LLPS). A visual representation shows an RGG peptide interacting with G4-DNA, forming LLPS droplets. The art highlights the importance of arginine′s specific interactions for LLPS, reflecting the study's insights into the molecular mechanisms driving G4-LLPS. More details can be found in article 10.1002/cmdc.202400460 by Daisuke Miyoshi and co-workers.
期刊介绍：
Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.
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