Two Ferrocene-Modified Copper(I) Complexes for the Synergistic Enhancement of Chemodynamic Therapy

Abstract

In recent years, some Cu-based complexes and nanomaterials that can better adapt to tumour microenvironments and produce better chemodynamic therapeutic effects have been synthesised. Ferrocene and its derivatives have garnered increasing attention as a therapeutic option in chemodynamic therapy owing to their excellent catalytic activity. Herein, two ferrocene-modified Cu(I) complexes, Fc-AD-Cu and Fc-IH-Cu, were synthesised with atomically precise structures. Both exhibit good Fenton/Fenton-like activity, inducing the generation of reactive oxygen species in Hep-G2 cells and improving chemodynamic therapeutic efficiency.