Comparison of offspring outcomes in women with and without epilepsy

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY Annals of Clinical and Translational Neurology Pub Date : 2025-02-03 DOI:10.1002/acn3.52316

Huali Luo, Xiaomin Mao, Shuli Zhu, Qiong Luo, Jiajia Fang, Qiwei Li

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Abstract

Objective

The potential impact of antiseizure medications (ASMs) on abortion rate and bone metabolism in the offspring of pregnant women with epilepsy (WWE) is currently unknown. This research aimed to assess the potential risk by conducting a comparative analysis of bone metabolism-related indicators in the offspring of WWE.

Methods

We retrospectively analyzed data from 83 epileptic parturients receiving antenatal care at our hospital and a co-operative hospital from January 1, 2012, to December 31, 2021, comparing them to a control group of 249 parturients. The study analyzed and compared the two groups' growth parameters, including delivery mode, femoral length, biparietal diameter, and birth weight. Differences in femoral length, biparietal diameter, and birth weight among different ASM groups were also examined.

Results

WWE were more likely to undergo a cesarean section with a lower abortion rate (55.4% vs. 37.3%, P = 0.004). After adjusting for potential confounding variables, offspring femoral length in WWE was significantly reduced compared to the control group (6.812 cm vs. 6.923 cm, P < 0.0001). Moreover, those born to WWE using multiple ASMs had significantly reduced femoral and biparietal lengths compared to those whose mothers used a single ASM or none (P < 0.0001). Additionally, birth weight was significantly lower in offspring of WWE using multiple ASMs than those not using ASM (P < 0.05).

Interpretation

WWE experienced fewer abortions but worse negative offspring outcomes. The bone metabolism of the offspring of WWE was decreased and exhibited shortened femoral length, particularly in those on multiple ASMs.

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有癫痫和无癫痫妇女后代结局的比较。

目的：目前尚不清楚抗癫痫药物（asm）对癫痫孕妇后代流产率和骨代谢的潜在影响。本研究旨在通过对WWE后代骨代谢相关指标的比较分析来评估潜在风险。方法：回顾性分析2012年1月1日至2021年12月31日在我院及合作医院接受产前护理的癫痫产妇83例的资料，并与对照组249例产妇进行比较。本研究分析比较两组的生长参数，包括分娩方式、股骨长度、双顶骨直径和出生体重。不同ASM组的股骨长度、双顶骨直径和出生体重也有差异。结果：WWE更容易接受剖宫产，流产率较低（55.4%比37.3%,P = 0.004）。在调整了潜在的混杂变量后，与对照组相比，WWE组的后代股骨长度显著减少（6.812 cm vs. 6.923 cm， P）。WWE后代的骨代谢降低，股骨长度缩短，特别是在多次asm的后代中。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.