Intersectionality in a sociogenomic world: How do race, disability, socioeconomic status, and polygenic prediction interact to affect perceptions of educational trajectories?

IF 6.2 1区 医学 Q1 GENETICS & HEREDITY Genetics in Medicine Pub Date : 2025-04-01 Epub Date: 2025-01-31 DOI:10.1016/j.gim.2025.101368
Lucas J. Matthews , Daphne O. Martschenko , Colby Lewis V , Maya Sabatello
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Abstract

Purpose

Education is important for lifelong skills and economic growth; however, student placement decisions may be shaped by social biases. As genomic information captured via polygenic scores becomes more available, it may also inform student placement decisions. We assessed the intersectional effects of polygenic scores, race, disability, and socioeconomic status on US adults’ views of educational trajectories using an online experimental survey design.

Methods

A total of 1367 US adults were randomized to one of 16 conditions and prompted to read a short vignette about a boy named Michael, also depicted in an image. Each condition varied Michael’s race (Black/White), disability (wheelchair user/no), socioeconomic status (high/low), and polygenic score (high/low) for educational attainment (EA-PGS). After reading the vignette, the respondents were asked to answer multichoice questions about Michael’s immediate and long-term educational trajectories.

Results

Variation in Michael’s EA-PGS strongly influenced participants’ expectations regarding (1) the most appropriate immediate educational program for Michael (ie, general, special, or gifted education), (2) whether he would graduate high school, and, if so, (3) the highest educational degree he would complete in his lifetime (associate, bachelor, master, or PhD). Across these responses, high EA-PGS was associated with more socially desirable outcomes, whereas the opposite was true for low EA-PGS. Depicting Michael in a wheelchair significantly influenced respondents’ expectations that his most appropriate immediate educational trajectory would be special. There were significant interactions between Michael’s race, disability, socioeconomic status, and the EA-PGS.

Conclusion

Information about children’s EA-PGS may affect their views about their immediate and long-term educational trajectories. The negative effects of low EA-PGS were comparable to those of high EA-PGS. The EA-PGS may be interpreted in ways that compound the existing stereotypes related to a child’s race, disability, and socioeconomic status.
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社会基因组世界中的交叉性:种族、残疾、社会经济地位和多基因预测如何相互作用,影响教育轨迹的感知?
目的:教育对终身技能和经济增长很重要,但学生的安置决定可能受到社会偏见的影响。随着通过多基因评分获得的基因组信息变得更加容易获得,它也可以为学生的安置决定提供信息。我们使用在线实验调查设计评估了多基因分数、种族、残疾和社会经济地位对美国成年人关于教育轨迹的看法的交叉影响。方法:1367名美国成年人被随机分配到16个条件中的一个,并被要求阅读一篇关于一个名叫“迈克尔”的男孩的短文,这也是一幅画。每种情况都改变了迈克尔的种族(黑人/白人)、残疾(轮椅使用者/非轮椅使用者)、社会经济地位(高/低)和教育程度(EA-PGS)的多基因得分(高/低)。在阅读完小短文后,受访者被要求回答有关迈克尔近期和长期教育轨迹的多项选择题。结果:Michael的EA-PGS的变化强烈影响了参与者对以下方面的期望:1)最适合Michael的即时教育计划(即普通教育、“特殊”教育或资优教育);2)他是否会高中毕业;如果是的话,3)他一生中能完成的最高教育学位(副学士、学士、硕士或博士)。在这些反应中,高EA-PGS与更多的社会期望结果相关,而低EA-PGS则相反。描绘坐在轮椅上的迈克尔显著影响了受访者的预期,即他最合适的直接教育轨迹将是“特殊”教育。Michael的种族、残疾、社会经济地位与EA-PGS之间存在显著的交互作用。结论:儿童EA-PGS的信息可能影响对其近期和长期教育轨迹的看法。低EA-PGS的负面影响与高EA-PGS的积极影响相当。EA-PGS的解释可能与现有的与儿童种族、残疾和社会经济地位相关的刻板印象相结合。
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来源期刊
Genetics in Medicine
Genetics in Medicine 医学-遗传学
CiteScore
15.20
自引率
6.80%
发文量
857
审稿时长
1.3 weeks
期刊介绍: Genetics in Medicine (GIM) is the official journal of the American College of Medical Genetics and Genomics. The journal''s mission is to enhance the knowledge, understanding, and practice of medical genetics and genomics through publications in clinical and laboratory genetics and genomics, including ethical, legal, and social issues as well as public health. GIM encourages research that combats racism, includes diverse populations and is written by authors from diverse and underrepresented backgrounds.
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