Intersectionality in a Sociogenomic World: How do Race, Disability, Socioeconomic Status, and Polygenic Prediction Interact to Impact Perceptions of Educational Trajectories?

IF 6.6 1区 医学 Q1 GENETICS & HEREDITY Genetics in Medicine Pub Date : 2025-01-31 DOI:10.1016/j.gim.2025.101368
Lucas J Matthews, Daphne O Martschenko, Colby Lewis V, Maya Sabatello
{"title":"Intersectionality in a Sociogenomic World: How do Race, Disability, Socioeconomic Status, and Polygenic Prediction Interact to Impact Perceptions of Educational Trajectories?","authors":"Lucas J Matthews, Daphne O Martschenko, Colby Lewis V, Maya Sabatello","doi":"10.1016/j.gim.2025.101368","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Education is important for life-long skills and economic growth, but student placement decisions may be shaped by social biases. As genomic information captured via polygenic scores becomes more available, it may also inform student placement decisions. We assessed the intersectional effects of polygenic scores, race, disability, and socioeconomic status on US adults' views about educational trajectories using an online experimental survey design.</p><p><strong>Methods: </strong>1,367 US adults were randomized to one of 16 conditions and prompted to read a short vignette about a boy named \"Michael,\" also depicted in an image. Each condition varied Michael's race (Black/White), disability (wheelchair-user/no), socioeconomic status (high/low), and polygenic score (high/low) for educational attainment (EA-PGS). After reading the vignette, respondents were asked to answer multi-choice questions about Michael's immediate and long-term educational trajectories.</p><p><strong>Results: </strong>Variation in Michael's EA-PGS strongly influenced participants' expectations regarding: 1) the most appropriate immediate educational program for Michael (i.e., general, 'special', or gifted education); 2) whether he would graduate high school; and, if so, 3) the highest educational degree he would complete in his lifetime (Associates, Bachelors, Masters, or PhD). Across these responses, high EA-PGS was associated with more socially desirable outcomes and the opposite was the case for low EA-PGS. Depicting Michael in a wheelchair significantly influenced respondents' expectation that his most appropriate immediate educational trajectory would be 'special' education. There were significant interactions between Michael's race, disability, socioeconomic status, and EA-PGS.</p><p><strong>Conclusion: </strong>Information about a child's EA-PGS may impact views about their immediate and long-term educational trajectories. The negative impacts of a low EA-PGS are comparable to the positive impacts of a high EA-PGS. EA-PGS may be interpreted in ways that compound existing stereotypes related to a child's race, disability, and socioeconomic status.</p>","PeriodicalId":12717,"journal":{"name":"Genetics in Medicine","volume":" ","pages":"101368"},"PeriodicalIF":6.6000,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genetics in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.gim.2025.101368","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: Education is important for life-long skills and economic growth, but student placement decisions may be shaped by social biases. As genomic information captured via polygenic scores becomes more available, it may also inform student placement decisions. We assessed the intersectional effects of polygenic scores, race, disability, and socioeconomic status on US adults' views about educational trajectories using an online experimental survey design.

Methods: 1,367 US adults were randomized to one of 16 conditions and prompted to read a short vignette about a boy named "Michael," also depicted in an image. Each condition varied Michael's race (Black/White), disability (wheelchair-user/no), socioeconomic status (high/low), and polygenic score (high/low) for educational attainment (EA-PGS). After reading the vignette, respondents were asked to answer multi-choice questions about Michael's immediate and long-term educational trajectories.

Results: Variation in Michael's EA-PGS strongly influenced participants' expectations regarding: 1) the most appropriate immediate educational program for Michael (i.e., general, 'special', or gifted education); 2) whether he would graduate high school; and, if so, 3) the highest educational degree he would complete in his lifetime (Associates, Bachelors, Masters, or PhD). Across these responses, high EA-PGS was associated with more socially desirable outcomes and the opposite was the case for low EA-PGS. Depicting Michael in a wheelchair significantly influenced respondents' expectation that his most appropriate immediate educational trajectory would be 'special' education. There were significant interactions between Michael's race, disability, socioeconomic status, and EA-PGS.

Conclusion: Information about a child's EA-PGS may impact views about their immediate and long-term educational trajectories. The negative impacts of a low EA-PGS are comparable to the positive impacts of a high EA-PGS. EA-PGS may be interpreted in ways that compound existing stereotypes related to a child's race, disability, and socioeconomic status.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Genetics in Medicine
Genetics in Medicine 医学-遗传学
CiteScore
15.20
自引率
6.80%
发文量
857
审稿时长
1.3 weeks
期刊介绍: Genetics in Medicine (GIM) is the official journal of the American College of Medical Genetics and Genomics. The journal''s mission is to enhance the knowledge, understanding, and practice of medical genetics and genomics through publications in clinical and laboratory genetics and genomics, including ethical, legal, and social issues as well as public health. GIM encourages research that combats racism, includes diverse populations and is written by authors from diverse and underrepresented backgrounds.
期刊最新文献
Patterns of X-linked inheritance: a new approach for the genome era. Biochemical testing for congenital disorders of glycosylation: A technical standard of the American College of Medical Genetics and Genomics (ACMG). Mainstreaming improved adoption of germline testing for Veterans Affairs patients with metastatic prostate cancer without exacerbating disparities. AUTS2-related Syndrome: Insights from a large European cohort. Efficacy of Transitioning from Alglucosidase Alfa to Avalglucosidase Alfa in Infantile-Onset Pompe Disease: A Single-Center Cohort Analysis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1