Multimodality Brain Imaging Markers in Progressive Supranuclear Palsy Subtypes and Parkinson's Disease.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY Movement Disorders Clinical Practice Pub Date : 2025-05-01 Epub Date: 2025-02-04 DOI:10.1002/mdc3.14346

Kanchana Soman Pillai, Parvathy Rajeswari, Ravindra B Kamble, Shagos Gopalan Nair Santhamma, Manas Chacko, Vijay Jayakrishnan, Ranjini Ramachandran, Ayana Avarachan, Asha Kishore

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Abstract

Background: The new classification of progressive supranuclear palsy (PSP) subtypes necessitates identifying radiological biomarkers to support the clinical diagnosis.

Objective: The goal was to test if magnetic resonance imaging (MRI) morphometry, diffusion tensor imaging (DTI), susceptibility-weighted imaging (SWI), or [18F]fluorodeoxyglucose (^18FFDG)-positron emission tomography (PET) differentiates PSP subtypes from each other or Parkinson's disease (PD).

Methods: Midbrain/pons (M/P) area ratio, middle/superior cerebellar peduncle (MCP/SCP) width ratio, magnetic resonance parkinsonism indices (MRPI and MRPI2) and midbrain antero-posterior (AP) diameter were measured. Region of interest-based DTI, SWI, and ^18FFDG-PET analyses were performed.

Results: Four PSP subtypes (n = 85) and 24 PD were studied. MRI morphometry and DTI could differentiate PSP-Richardson syndrome (PSP-RS) from PSP-parkinsonism, PSP-postural instability, and PD (area under curve >0.7). SWI did not differentiate among PSP subtypes or PD. ^18FFDG-PET distinguished PSP from PD.

Conclusions: MRI morphometry and DTI differentiated PSP-RS from the other common PSP subtypes and PD and may be tested as a radiological marker of PSP-RS in larger studies.

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进行性核上性麻痹亚型和帕金森病的多模态脑成像标志物

背景：进行性核上性麻痹（PSP）亚型的新分类需要确定放射生物标志物来支持临床诊断。目的：目的是测试磁共振成像（MRI）形态学、扩散张量成像（DTI）、敏感性加权成像（SWI）或[18F]氟脱氧葡萄糖(18FFDG)-正电子发射断层扫描（PET）是否能区分PSP亚型或帕金森病（PD）。方法：测量中脑/脑桥（M/P）面积比、小脑中/上脚（MCP/SCP）宽度比、磁共振帕金森症指数（MRPI和MRPI2）及中脑前后径（AP）。进行了基于兴趣区域的DTI、SWI和18FFDG-PET分析。结果：研究了4种PSP亚型（n = 85）和24例PD。MRI形态学和DTI可以将psp -理查德森综合征（PSP-RS）与psp -帕金森症、psp -体位不稳定和PD（曲线下面积>0.7）区分。SWI在PSP亚型和PD之间没有区别。18FFDG-PET区分PSP和PD。结论：MRI形态学和DTI将PSP- rs与其他常见的PSP亚型和PD区分开来，并可能在更大规模的研究中作为PSP- rs的放射学标志物。

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)