Harman Sharma, Sarah K Manning, Natalie E Stevens, Georgia Bourlotos, Feargal J Ryan, Cindy Tay, Sonja Klebe, Geraint B Rogers, David J Lynn, Steven L Taylor, Luke Grundy
{"title":"Acute urinary tract infection elicits bladder afferent hypersensitivity.","authors":"Harman Sharma, Sarah K Manning, Natalie E Stevens, Georgia Bourlotos, Feargal J Ryan, Cindy Tay, Sonja Klebe, Geraint B Rogers, David J Lynn, Steven L Taylor, Luke Grundy","doi":"10.1016/j.bbih.2025.100944","DOIUrl":null,"url":null,"abstract":"<p><p>•We explored the neurophysiology underlying painful bladder sensations during UTI.•UTI induces significant bladder afferent hypersensitivity during distension.•Low-threshold afferents elicit exaggerated responses at normal bladder pressures.•Afferent hypersensitivity correlated with the development of bladder dysfunction.•Bladder afferents are key regulators of sensory and behavioural responses to UTI.</p>","PeriodicalId":72454,"journal":{"name":"Brain, behavior, & immunity - health","volume":"44 ","pages":"100944"},"PeriodicalIF":3.7000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788684/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain, behavior, & immunity - health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.bbih.2025.100944","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
•We explored the neurophysiology underlying painful bladder sensations during UTI.•UTI induces significant bladder afferent hypersensitivity during distension.•Low-threshold afferents elicit exaggerated responses at normal bladder pressures.•Afferent hypersensitivity correlated with the development of bladder dysfunction.•Bladder afferents are key regulators of sensory and behavioural responses to UTI.
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