Visible-light induced direct C(sp3)-H bond disulfidation of saturated N-heterocycles through a hydrogen atom transfer (HAT) process

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC Organic Chemistry Frontiers Pub Date : 2025-02-05 DOI:10.1039/d4qo02384f

Junlei Wang, Guocheng Gao, Chengcheng Shi, Han Gao, Ji Luo, Guofen Wei, Daohai Zhang, Hongqing Li, Tonghao Yang, Binbin Huang

引用次数: 0

Abstract

We report herein a direct disulfidation of N-α-C(sp3)-H bonds of saturated N-heterocycles, affording a wide range of disulfidation products in moderate to good yields. The method is enabled by merging visible-light photoredox and hydrogen atom transfer (HAT) catalysis, exhibiting good functional group tolerance. Gram scale transformation indicates the potential utility of this method in practical synthesis. Preliminary mechanistic studies indicate that hydrogen atom transfer is critical for the transformation.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.