Effectiveness of brain magnetic resonance imaging in the early diagnosis and characterization of dementias: A systematic review

Medicina clinica (English ed.) Pub Date : 2024-12-13 Epub Date: 2024-11-01 DOI:10.1016/j.medcle.2024.05.025

Ana María Ruiz Tornero , Esther E. García Carpintero , Begoña Rodríguez Ortiz de Salazar

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Abstract

Introduction

Magnetic resonance imaging (MRI) is a frequently used test in the diagnosis of dementia. The objective was to evaluate its effectiveness for the early diagnosis of dementia in patients with mild cognitive impairment (MCI).

Material and methods

Original studies were selected from systematic reviews between 2011 and 2021, according to PRISMA 2020 criteria. QUADAS-2 and GRADE tools were used, and a meta-analysis was performed.

Results

Final selection of 23 articles. Patient selection and index test had a high probability of bias. The certainty of the evidence was very low. In the hippocampus, sensitivity was 0.62 (95%CI 0.48–0.79) and specificity 0.70 (95%CI 0.55–0.80). In the temporal lobe, sensitivity was 0.65 (range 0.45) and specificity 0.69 (range 0.32).

Conclusions

There is insufficient evidence to recommend routine brain MRI for the early diagnosis of dementia in patients with MCI.

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脑磁共振成像在痴呆早期诊断和表征中的有效性：一项系统综述

磁共振成像（MRI）是一种常用的痴呆症诊断方法。目的是评估其对轻度认知障碍（MCI）患者痴呆早期诊断的有效性。材料和方法根据PRISMA 2020标准，从2011年至2021年的系统综述中选择原始研究。采用QUADAS-2和GRADE工具，并进行meta分析。结果最终入选23篇。患者选择和指标检验存在较大的偏倚概率。证据的确定性很低。在海马区，敏感性为0.62 (95%CI 0.48-0.79)，特异性为0.70 （95%CI 0.55-0.80）。在颞叶，敏感性为0.65（范围0.45），特异性为0.69（范围0.32）。结论推荐常规脑MRI早期诊断轻度认知损伤患者痴呆的证据不足。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medicina clinica (English ed.)

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