Effectiveness of brain magnetic resonance imaging in the early diagnosis and characterization of dementias: A systematic review

Medicina clinica (English ed.) Pub Date : 2024-12-13 DOI:10.1016/j.medcle.2024.05.025

Ana María Ruiz Tornero , Esther E. García Carpintero , Begoña Rodríguez Ortiz de Salazar

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Abstract

Introduction

Magnetic resonance imaging (MRI) is a frequently used test in the diagnosis of dementia. The objective was to evaluate its effectiveness for the early diagnosis of dementia in patients with mild cognitive impairment (MCI).

Material and methods

Original studies were selected from systematic reviews between 2011 and 2021, according to PRISMA 2020 criteria. QUADAS-2 and GRADE tools were used, and a meta-analysis was performed.

Results

Final selection of 23 articles. Patient selection and index test had a high probability of bias. The certainty of the evidence was very low. In the hippocampus, sensitivity was 0.62 (95%CI 0.48–0.79) and specificity 0.70 (95%CI 0.55–0.80). In the temporal lobe, sensitivity was 0.65 (range 0.45) and specificity 0.69 (range 0.32).