AGE-STRATIFIED ANALYSIS OF ANTI-MüLLERIAN HORMONE (AMH) LEVELS AND THE PREVALENCE OF DIMINISHED OVARIAN RESERVE IN A POPULATION OF 22,920 WOMEN AGED 18-45: A RETROSPECTIVE STUDY

IF 3.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY Reproductive biomedicine online Pub Date : 2024-11-01 Epub Date: 2024-12-04 DOI:10.1016/j.rbmo.2024.104550

Kiper Aslan , Aylin Tunali , İlayda Tellioğlu , Isil Kasapoglu , Gurkan Uncu

{"title":"AGE-STRATIFIED ANALYSIS OF ANTI-MüLLERIAN HORMONE (AMH) LEVELS AND THE PREVALENCE OF DIMINISHED OVARIAN RESERVE IN A POPULATION OF 22,920 WOMEN AGED 18-45: A RETROSPECTIVE STUDY","authors":"Kiper Aslan , Aylin Tunali , İlayda Tellioğlu , Isil Kasapoglu , Gurkan Uncu","doi":"10.1016/j.rbmo.2024.104550","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Anti-Müllerian hormone (AMH) is recognized as the most reliable indicator of ovarian reserve and is widely utilized in various clinical settings. AMH concentrations consistently decline as women age. Despite its widespread use, the lack of standardized, age-specific reference ranges for AMH in reproductive-aged women restricts its full clinical utility. This retrospective analysis aims to explore age-stratified AMH levels and establish the prevalence of diminished ovarian reserve (DOR) at different ages.</div></div><div><h3>Methods</h3><div>The study was conducted at a tertiary university hospital. An electronic database was screened for AMH results between the years 2015-2024. All analyzed AMH results were recorded regardless of the purpose of the analysis. Women aged between 18-45 were enrolled, ensuring each patient was only included once to avoid duplications. Correlation analysis was performed to show the relationship between AMH and age. Median AMH values for each age group were calculated, and the prevalence of diminished ovarian reserve according to AMH levels was analyzed. The Poseidon Criteria were used to define diminished ovarian reserve (<1.2 ng/ml).</div></div><div><h3>Results</h3><div>A total of 24,587 AMH results were found in the electronic database for the years 2015-2024. After excluding duplications and results for women older than 45 and younger than 18, 22,920 AMH results were analyzed. Correlation analysis showed a significant relationship between AMH levels and age. As age increased, AMH levels significantly decreased. By age 36, median AMH levels had decreased below 1.2 ng/ml. The prevalence of DOR was 15.9% at age 18, while this ratio was nearly 96% at age 45.</div></div><div><h3>Conclusion</h3><div>This study presented age-stratified AMH levels for a large population of over 20,000 women. Although the study population consisted of patients from a tertiary hospital, the results may be beneficial in establishing age-specific AMH levels in clinical practice.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 ","pages":"Article 104550"},"PeriodicalIF":3.5000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproductive biomedicine online","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1472648324007399","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Anti-Müllerian hormone (AMH) is recognized as the most reliable indicator of ovarian reserve and is widely utilized in various clinical settings. AMH concentrations consistently decline as women age. Despite its widespread use, the lack of standardized, age-specific reference ranges for AMH in reproductive-aged women restricts its full clinical utility. This retrospective analysis aims to explore age-stratified AMH levels and establish the prevalence of diminished ovarian reserve (DOR) at different ages.

Methods

The study was conducted at a tertiary university hospital. An electronic database was screened for AMH results between the years 2015-2024. All analyzed AMH results were recorded regardless of the purpose of the analysis. Women aged between 18-45 were enrolled, ensuring each patient was only included once to avoid duplications. Correlation analysis was performed to show the relationship between AMH and age. Median AMH values for each age group were calculated, and the prevalence of diminished ovarian reserve according to AMH levels was analyzed. The Poseidon Criteria were used to define diminished ovarian reserve (<1.2 ng/ml).

Results

A total of 24,587 AMH results were found in the electronic database for the years 2015-2024. After excluding duplications and results for women older than 45 and younger than 18, 22,920 AMH results were analyzed. Correlation analysis showed a significant relationship between AMH levels and age. As age increased, AMH levels significantly decreased. By age 36, median AMH levels had decreased below 1.2 ng/ml. The prevalence of DOR was 15.9% at age 18, while this ratio was nearly 96% at age 45.

Conclusion

This study presented age-stratified AMH levels for a large population of over 20,000 women. Although the study population consisted of patients from a tertiary hospital, the results may be beneficial in establishing age-specific AMH levels in clinical practice.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

22920名18-45岁女性抗勒氏激素（amh）水平和卵巢储备功能减退的年龄分层分析：一项回顾性研究

目的抗勒氏激素（AMH）被认为是卵巢储备最可靠的指标，在各种临床环境中得到广泛应用。AMH浓度随着女性年龄的增长而持续下降。尽管AMH被广泛使用，但在育龄妇女中缺乏标准化的、特定年龄的参考范围，限制了其充分的临床应用。本回顾性分析旨在探讨年龄分层AMH水平，并确定卵巢储备功能减退（DOR）在不同年龄的患病率。方法本研究在某三级大学附属医院进行。在2015-2024年期间筛选AMH结果的电子数据库。无论分析的目的如何，所有分析的AMH结果都被记录下来。年龄在18-45岁之间的女性被纳入，确保每位患者只被纳入一次，以避免重复。对AMH与年龄的关系进行相关分析。计算各年龄组AMH的中位值，并根据AMH水平分析卵巢储备功能下降的患病率。采用Poseidon标准定义卵巢储备功能减退（1.2 ng/ml）。结果2015-2024年电子数据库共收录AMH结果24587份。在排除重复和45岁以上和18岁以下女性的结果后，分析了22,920个AMH结果。相关分析显示AMH水平与年龄有显著相关。随着年龄的增长，AMH水平显著降低。到36岁时，中位AMH水平已降至1.2 ng/ml以下。18岁时DOR的患病率为15.9%，而45岁时这一比例接近96%。结论本研究显示了2万多名妇女AMH水平的年龄分层。虽然研究人群由来自三级医院的患者组成，但结果可能有助于在临床实践中确定年龄特异性AMH水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Reproductive biomedicine online 医学-妇产科学

CiteScore

7.20

自引率

7.50%

发文量

391

审稿时长

50 days

期刊介绍： Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients. Context: The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.