AGE-STRATIFIED ANALYSIS OF ANTI-MüLLERIAN HORMONE (AMH) LEVELS AND THE PREVALENCE OF DIMINISHED OVARIAN RESERVE IN A POPULATION OF 22,920 WOMEN AGED 18-45: A RETROSPECTIVE STUDY
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Abstract
Objective
Anti-Müllerian hormone (AMH) is recognized as the most reliable indicator of ovarian reserve and is widely utilized in various clinical settings. AMH concentrations consistently decline as women age. Despite its widespread use, the lack of standardized, age-specific reference ranges for AMH in reproductive-aged women restricts its full clinical utility. This retrospective analysis aims to explore age-stratified AMH levels and establish the prevalence of diminished ovarian reserve (DOR) at different ages.
Methods
The study was conducted at a tertiary university hospital. An electronic database was screened for AMH results between the years 2015-2024. All analyzed AMH results were recorded regardless of the purpose of the analysis. Women aged between 18-45 were enrolled, ensuring each patient was only included once to avoid duplications. Correlation analysis was performed to show the relationship between AMH and age. Median AMH values for each age group were calculated, and the prevalence of diminished ovarian reserve according to AMH levels was analyzed. The Poseidon Criteria were used to define diminished ovarian reserve (<1.2 ng/ml).
Results
A total of 24,587 AMH results were found in the electronic database for the years 2015-2024. After excluding duplications and results for women older than 45 and younger than 18, 22,920 AMH results were analyzed. Correlation analysis showed a significant relationship between AMH levels and age. As age increased, AMH levels significantly decreased. By age 36, median AMH levels had decreased below 1.2 ng/ml. The prevalence of DOR was 15.9% at age 18, while this ratio was nearly 96% at age 45.
Conclusion
This study presented age-stratified AMH levels for a large population of over 20,000 women. Although the study population consisted of patients from a tertiary hospital, the results may be beneficial in establishing age-specific AMH levels in clinical practice.
期刊介绍：
Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients.
Context:
The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.
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